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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report Date:
1990

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Not stated
- Age at study initiation: Not stated
- Weight at study initiation: 200 - 300 g
- Fasting period before study: No
- Housing: Not stated
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Not stated


ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not stated
- Humidity (%): Not stated
- Air changes (per hr): Not stated
- Photoperiod (hrs dark / hrs light): Not stated

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: no data
Details on inhalation exposure:
The vapour was produced by enclosing approximately 100 g of the test substance in a sealed 100 to 151 L animal chamber for approximately 18 hours (static conditions). A mixing fan periodically aggitated the chamber atmosphere. Oxygen was added as required to maintain a chamber oxygen content of approximately 20%. If deaths occurred, exposure times were varied to determine an LT50.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 6 h
Concentrations:
Saturated vapour
No. of animals per sex per dose:
Five
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weights: day 0 (prior to exposure), day 7 and day 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology
Statistics:
None

Results and discussion

Effect levels
Sex:
male/female
Effect level:
other: saturated vapour
Exp. duration:
6 h
Remarks on result:
other: No deaths
Mortality:
No deaths occurred
Clinical signs:
other: Fur slightly moist, periodic rubbing of head, eyes and nose during exposure. Recovery occurred within one hour of the end of exposure.
Body weight:
No effects on body weight gain
Gross pathology:
No findings
Other findings:
No other findings reported

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
In a good quality (reliability score 2) acute inhalation toxicity study, not conducted to GLP, 3-trimethoxysilylpropane-1-thiol did not cause any deaths in Sprague-Dawley rats following a six hour exposure to a saturated vapour.
Executive summary:

In an acute inhalation study comparable to OECD test guideline 403, but not conducted to GLP, Sprague-Dawley rats were exposure to a saturated vapour of 3 -trimethoxysilylpropane-1-thiol for six hours. They were then observed for 14 days. No deaths occurred and there was no effect on body weight gain. Fur slightly moist, periodic rubbing of head, eyes and nose during exposure. Recovery occurred within one hour of the end of exposure. There were no abnormal findings during the gross pathological examinations.