Registration Dossier
Registration Dossier
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EC number: 219-143-7 | CAS number: 2372-21-6
Endpoint summary
Administrative data
Description of key information
Several aquatic studies have been performed.
An estimation of the LC50 for adult fish species was made. The effects on newly fertilized zebra fish eggs and hatchlings over an exposure period of 96 hours according to the OECD 236 were determined. The test substance has a predicted adult fish LC50 of > 10 and < 100 mg/L. 10 mg/L shall be used as worst case for chemical safety assessment. ECOSAR is used as qualitative weight of evidence that fish is not the most sensitive endpoint, algae is the most sensitive endpoint (experimentally and qualitatively from ECOSAR).
The acute toxicity of the test chemical to Daphnia Magna was determined according to OECD 202 in a semi-static system over an exposure period of 48 hours.
The highest test concentration showed only 30% effect, so an EC50 was not reached.
A NOEC of 0.9 mg/L and a LOEC of 1.5 mg/L were determined. The EC50 (48h) may be expressed as >3.6 mg/L.
The toxicity of the test chemical to an exponentially growing culture of P. subcapitata was determined over an exposure period of 72 hours.
The ErC10 is 0.002 mg/L and the ErC50 is 0.059 mg/L.
A first brood screening study has been performed with Daphnia magna. The study was not performed under GLP and can be used as range finding study for the definitive OECD 210 study.
Chemical analyses were performed. The endpoint is based on time weighted mean measured concentrations. No effects were seen up to the highest test concentration of 0.63 mg/L, therefore NOEC ≥ 0.63 mg/L.
Toxicity to microorganisms was determined as well in an activated sludge respiration inhibition test was performed according to OECD 209.
The EC50 (3h) of the substance for activated sludge is 530 mg/L. The EC10, EC20 and EC80 are 18, 58 and 4861 mg/L, respectively.
Additional information
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