Registration Dossier
Registration Dossier
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EC number: 220-744-1 | CAS number: 2885-00-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Octadecane-1-thiol
- EC Number:
- 220-744-1
- EC Name:
- Octadecane-1-thiol
- Cas Number:
- 2885-00-9
- Molecular formula:
- C18H38S
- IUPAC Name:
- octadecane-1-thiol
- Test material form:
- solid: bulk
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 5 males and 5 females
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Details on oral exposure:
- ODM formulated to 20% w/v in 1% w/v aqueous methyl cellulose and adminstered at a dose volume of 10ml/kg bw.
- Doses:
- 2000mg/lg bw.
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- Animals were monitored for 14 days and autopsied on the 15th day.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Mortality:
- No mortalities
- Clinical signs:
- other: Piloerection observed 5 minutes after dosing. This persisted on day 2 but there were no observed signs and full recovery by day 5 in all animals.
- Gross pathology:
- Not monitored.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Based on CLP classification it is not classified as exhibiting oral toxicity.
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