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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2012

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified
Remarks:
The cited reference refers to unpublished data from Elf Atochem dating back to 1977 where GLP compliance was not normally specified.

Test material

Constituent 1
Chemical structure
Reference substance name:
Octadecane-1-thiol
EC Number:
220-744-1
EC Name:
Octadecane-1-thiol
Cas Number:
2885-00-9
Molecular formula:
C18H38S
IUPAC Name:
octadecane-1-thiol
Test material form:
solid: bulk

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
Not specified
Duration of treatment / exposure:
4 hours
Observation period:
Not specified
Number of animals:
'no specified

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
> 0 - <= 0.5
Reversibility:
not specified
Remarks on result:
probability of weak irritation
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
> 0 - <= 0.5
Reversibility:
not specified
Remarks on result:
probability of weak irritation

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Results showed very mild skin irritant effects.