Registration Dossier
Registration Dossier
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EC number: 446-990-1 | CAS number: -
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2007-10-15
Test material
- Reference substance name:
- -
- EC Number:
- 446-990-1
- EC Name:
- -
- Molecular formula:
- C5H11O5 [C6H10O5]1.45 and C5H10O4 and C5H12O5
- IUPAC Name:
- 2-(hydroxymethyl)oxolane-3,4-diol; 5-{[2,3,4,5-tetrahydroxy-6-(xenoniooxy)hexyl]oxy}pentane-1,2,3,4-tetrol; pentane-1,2,3,4,5-pentol
- Details on test material:
- description: yellow solid gel
batch number: 1484JG
Received: 2008-04-07
Storage conditions: room temperature in the dark
Constituent 1
Study design
- Buffers:
- Specification of buffer solutions
pH 4: using 0.1M hydrochloric acid
pH 7: using 0.1M sodium hydroxide
pH 9: using 0.1M sodium hydroxide
Duration of testopen allclose all
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50
- Initial conc. measured:
- ca. 1 g/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50
- Initial conc. measured:
- ca. 1 g/L
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50
- Initial conc. measured:
- ca. 1 g/L
- Number of replicates:
- 2
- Positive controls:
- yes
- Negative controls:
- yes
Results and discussion
- Transformation products:
- not measured
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 120 h
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 120 h
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 120 h
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Estimated half-life at 25°C for pH 4 / 7 / 9:
> 1 year - Executive summary:
Title: hydrolysis as a function of pH
Assessment of hydrolytic stability was carried out using Method 111 of the OECD guidelines for Testing of chemical, 13 April 2004.
The concentration of the sample solution was determined by gas chromatography (GC).
Test were done in duplicate.
There results are as follow:
Estimated half-life at 25°C for pH 4 / 7 / 9:
> 1 year
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