2-(undec-10-enoylamino)-3-phenylpropanoic acid

Surface tension

Administrative data

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2009-03-25 - 2009-08-20

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP Guideline Study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2009

Report date:

2009

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

ring method

Test material

Test material information

Constituent 1

Reference substance name:

LCa08042

IUPAC Name:

LCa08042

Details on test material:

- Name of test material (as cited in study report): LCA08042
- Substance type: white and beige solid
- Physical state: solid
- Analytical purity: 99.4%
- Lot/batch No.: 0826000002
- Expiration date of the lot/batch: September 16, 2001
- Storage condition of test material: At room temperature (about 20°C)

Results and discussion

Surface tension

Surface tension:

50.2 mN/m

Temp.:

20.3 °C

Conc.:

0.1 vol%

Any other information on results incl. tables

Table 1: Determination of the Calibration factor using water

Time expired [h:min]	Temperature [°C]	Surface tension		Calibration factor (F)
		measured	Mean(sg)
00:32	19.8	70.7	70.30	1.0353
00:33	19.8	70.2
00:34	19.8	70.2
00:35	19.8	70.2
00:36	19.8	70.2
00:37	19.8	70.3

 

With         s_o= 72.78 mN/m at 20.0°C

                 F=s_o/s_g

                 F= 72.78 / 70.30 = 1.0353

 

Where     F= Calibration factor

                 s_o= Surface tension of water at the test temperature

                 s_g= Measured value of the surface tension of water at the test temperature

 

 

Table 2: Determination of the surface tension for the test item solution

Time expired [h:min]	Temperature [°C]	Surface tension measured	[mN/m]
			Mean value (s*)	Mean corrected for calibration (s1)	Mean corrected for Harkins-Jordan (s)
First sample
00:34	20.2	50.1	49.78	51.54	50.22
00:35	20.2	49.8
00:36	20.2	49.7
00:37	20.2	49.7
00:38	20.2	49.7
00:39	20.2	49.7
Second sample
00:31	20.3	49.9	49.73	51.49	50.16
00:32	20.3	49.7
00:33	20.3	49.7
00:34	20.3	49.7
00:35	20.3	49.7
00:36	20.3	49.7

 

Mean value from both samples:s= 50.2 mN/m

 

With s*×F=s₁                                F= Calibration factor = 1.0353

and s₁×F_c=s                                  F_c= Correction factor acc. to Harkins

                        = 0.974 for 51.54 mN/m and 0.974 for 51.49 mN/m

 

 

Applicant's summary and conclusion

Conclusions:

The surface tension of LCA08042 in water (at a concentration of about 0.1%) was determined to be 50.2 mN/m at 20.3 °C ± 0.1 °C.
Based on the criteria as outlined in the EEC Guideline, LCA08042 is a surface active substance.

Executive summary:

The determination of the surface tension of an aqueous solution of LCA08042 was based on the OECD Guideline No. 115: “Surface Tension of Aqueous Solutions” (1995) and on the EEC Directive 92/69, EEC Publication No. L383, December 1992 and the Council Regulation (EC) No. 440/2008, 30 May 2008, Part A, Methods for the determination of physico-chemical properties, A.5 “Surface tension”.

The surface tension of LCA08042 in water (at a concentration of about 0.1%) was determined to be 50.2 mN/m at 20.3 °C ± 0.1 °C. Based on the criteria as outlined in the EEC Guideline, LCA08042 is a surface active substance.