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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: EU guideline, GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
2003-02-13
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Reference substance name:
sepiwhite MSH
IUPAC Name:
sepiwhite MSH
Details on test material:
description: off-white powder
batch number: 0214400005
received: 13 October 2003
storage conditions: approximately 4°C in the dark

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
ca. 3.3
pH:
ca. 2
Remarks on result:
other: HPLC method
Type:
log Pow
Partition coefficient:
ca. -0.04
pH:
ca. 7
Remarks on result:
other: calculated

Applicant's summary and conclusion

Conclusions:
The partition coefficient of the test material has been determined to be 2.14/10^3, log 10 Pow 3.33at pH2, log10 Pow -0.04, calculated at pH 7.
Executive summary:

Partition coefficient.

2.14*10^3, log Pow 3.33 at pH 2, using the HPLC method, Method A8 od Comission Directive 92/69/EEC, log10 Pow -0.04, calculated at pH 7.