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EC number: 947-361-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
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- Viscosity
- Additional physico-chemical information
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- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
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- Repeated dose toxicity
- Genetic toxicity
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- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
No study is available for the target substance, but four acute oral toxicity studies and one acute dermal toxicity study in rats are available performed with the partially unsaturated TEA-Esterquat. Here, the oral LD50 was determined to be > 5000 mg/kg bw in rats. The dermal LD50 was > 2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- EU Method B.1 (Acute Oral Toxicity)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- OECD Guideline 402 (Acute Dermal Toxicity)
Additional information
oral
In an acute oral toxicity study (according to EU Method B 1), 5 Sprague-Dawley rats/sex/dose were given single oral doses of 2000 or 5000 mg/kg bw of the “partially unsaturated TEA-Esterquat” (89.6 % a.i.) and observed for 14 days. No animal died. No clinical signs or effects on body weight were observed at 2000 mg/kg bw. Hypokinesia was noted only in the treated males at the dose level of 5000 mg/kg bw, 30 minutes and one hour after treatment, then in all the animals after 2 and 4 hours. From day 2 to day 15, no clinical signs were observed at the dose level of 5000 mg/kg bw. These findings were accompanied by a slight slowed down of the body weight gain between day 1 and day 5 in the males at 5000 mg/kg bw. Normal weight gain was observed in the female 5000 mg/kg bw group. Gross pathological examinations at 14 days p.a. (terminal necropsy) revealed no test article-dependent findings. The oral LD50 for males and females is > 5000 mg/kg bw (nominal).
These findings were supported by three additional reliable studies in the rat according to OECD guideline 401. Animals were treated with partially unsaturated TEA-Esterquat at single oral doses of 2000 mg/kg bw in two studies and in one study with 2000 and 5000 mg/kg bw, respectively, and observed for 14 days. In none of these studies mortality, relevant clinical signs or effects on body weight were observed. Gross pathological examinations at terminal necropsy revealed no test article-dependent findings in neither of the studies. The partially unsaturated TEA-Esterquat is considered to be practically non-toxic based on the oral LD50 of > 5000 mg/kg bw (nominal).
dermal
In an acute dermal toxicity study according to OECD guideline 402, 5 male and 5 female young adult CD rats were dermally exposed to the partially unsaturated TEA-Esterquat suspended in water for 24 hours under an occlusive dressing to approx. 10 % of body surface area at doses of 2000 mg/kg bw. Animals then were observed for 14 days. No mortality occurred in this limit test. No clinical signs were observed. No macroscopic changes were noted at gross pathological examinations at terminal necropsy. Normal weight gain was observed, except for one female rat. Its body weight gain was slightly reduced. The partially unsaturated TEA-Esterquat is practically non-toxic based on the dermal LD50 of > 2000 mg/kg bw determined in this study.
In conclusion the oral and dermal LD50 for TEA-Esterquat is assessed to be > 2000 mg/kg bw.
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. The acute oral and dermal LD50 was greater than 2000 mg/kg bw for all TEA-Esterquats. As a result the substance is not considered to be classified for acute oral or dermal toxicity under Regulation (EC) No 1272/2008, as amended for the tenth time in Regulation (EU) No 2017/ 776.
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