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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1937

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
- Principle of test: Determination of the acute oral toxicity in rabbits.
GLP compliance:
no
Remarks:
pre-GLP study

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1-diethoxyethane
EC Number:
203-310-6
EC Name:
1,1-diethoxyethane
Cas Number:
105-57-7
Molecular formula:
C6H14O2
IUPAC Name:
1,1-diethoxyethane
Test material form:
liquid

Test animals

Species:
rabbit

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
15, 20, 25, 28.5, and 30 mmol/kg bw
No. of animals per sex per dose:
5 - 8

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 360 - < 3 540 mg/kg bw
Based on:
test mat.
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 20 - < 30 other: mmol/kg
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Executive summary:

In the review article, an LD50 range between 2360 and 3540 mg/kg bw for the acute oral toxicity of the test item in rabbits is reported.