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EC number: 259-869-1 | CAS number: 55860-53-2
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial plants: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- EPI Suite v 4.1/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable. QSAR model
- Analytical monitoring:
- not required
- Vehicle:
- no
- Species:
- other: Terrestrial plants,QSAR model
- Plant group:
- other: QSAR model
- Details on test organisms:
- no further information
- Test type:
- other: QSAR
- Study type:
- other: QSAR
- Substrate type:
- other: QSAR
- Limit test:
- no
- Total exposure duration:
- 30 d
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Moisture:
- not applicable. QSAR model
- Details on test conditions:
- SMILES : O(C(=NCC)S)CC(C)C
CHEM : Carbamothioic acid, ethyl-, o-(2-methylpropyl) ester
CAS Num: 55860-53-2
MOL FOR: C7 H15 N1 O1 S1
MOL WT : 161.26
Log Kow: 3.81 (KowWin estimate)
Wat Sol: 37.72 mg/L (WskowWin estimate) - Reference substance (positive control):
- no
- Species:
- other: Terrestrial plants,QSAR model
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2.441 mg/kg soil dw
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Remarks on result:
- other: 1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
- Species:
- other: Terrestrial plants,QSAR model
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.261 mg/kg soil dw
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Remarks on result:
- other: cited as a ChV value, 1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
- Details on results:
- The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 1.261 mg/L (ppm) for terrestrial plants.
The ECOSAR QSAR model predicts that 96-hr EC50 valuewould to be 2.441 mg/L (ppm) for terrestrial plants.
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same. - Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 1.261 mg/L (ppm) for terrestrial plants.
The ECOSAR QSAR model predicts that 96-hr EC50 valuewould to be 2.441 mg/L (ppm) for terrestrial plants.
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same. - Executive summary:
The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 1.261 mg/L (ppm) for terrestrial plants.
The ECOSAR QSAR model predicts that 96-hr EC50 valuewould to be 2.441 mg/L (ppm) for terrestrial plants.
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
- Endpoint:
- toxicity to terrestrial plants: long-term
- Data waiving:
- exposure considerations
- Justification for data waiving:
- the study does not need to be conducted because direct and indirect exposure of the soil compartment is unlikely
Referenceopen allclose all
Overview of QSARs estimations ontoxicity of O-isobutyl ethylthiocarbamate to terrestrial plants
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
Terrestrial plants ,96-hrEC50 = 2.441 mg/L (ppm) Terrestrial plants, 30-day, ChV (chronic value) =1.261 mg/L(ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
Terrestrial plants ,96-hrEC50 = 2.441 mg/L (ppm)
Terrestrial plants, 30-day, ChV (chronic value) =1.261 mg/L(ppm)
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
Description of key information
The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 1.261 mg/L (ppm) for terrestrial plants.
The ECOSAR QSAR model predicts that 96-hr EC50 valuewould to be 2.441 mg/L (ppm) for terrestrial plants.
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for terrestrial plants:
- 2.441 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for terrestrial plants:
- 1.261 mg/kg soil dw
Additional information
According to “ANNEX IX- STANDARD INFORMATION REQUIREMENTS FOR SUBSTANCES MANUFACTURED OR IMPORTED IN QUANTITIES OF 100 TONNES OR MORE , study for effects on terrestrial organisms and plants need not be conducted if: - These studies do not need to be conducted if direct and indirect exposure of the soil compartment is unlikely
No terrestrial toxicity data are reported forO-isobutyl ethylthiocarbamate. Given the low potential for O-isobutyl ethylthiocarbamate reaching the terrestrial compartments (EQC modelling results), the lack of persistence (ready biodegradability under aerobic conditions) or bioaccumulation (BCFWIN modelling results), and the low likelihood of the chemicalpartitioning to soil and sediments (EQC modelling results), the lack of ecotoxicity data is not considered a deficiency
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