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EC number: 479-480-2 | CAS number: 17852-52-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.13, B.14 (Ames-Test); OECD 471
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: sat TA 98, 100, 102, 1535, 1537; esc WP2 uvrA
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 312.5 ... 5000 µg/plate
Concentration range in the main test (without metabolic activation): 312.5 ... 5000 µg/plate - Vehicle / solvent:
- Solvent: Destillieres Wasser
- Details on test system and experimental conditions:
- Metabolic activation system: Das Gemisch S9 (S9-Mix) wurde aus einer post-mitochondrialen
Fraktion aus Lebern der Ratten, die mit Aroclor 1254
vorbehandelt wurden, vorbereitet.
"ENGLISH"
The S9 mix was prepared from a post-mitochondrial fraction
from livers of the rats which were pretreated with aroclor
1254.
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 µg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 µg/plate)
- Additional information on results:
- Observations:
Kein Niederschlag wurde bei den geprüften Dosierungsstufen
bemerkt.
"ENGLISH"
No precipitation was observed at the tested dose levels. - Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive with metabolic activation
positive without metabolic activation
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