Registration Dossier
Registration Dossier
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EC number: 241-165-0 | CAS number: 17096-07-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- other: An assessment of TK properties is made based on the available information as per Annex VIII of REACH
- Adequacy of study:
- other information
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Executive summary:
ABSORPTION
Oral / GI tract
The substance has a molecular weight of 450 and is insoluble in water, therefore significant absorption is unlikely. However, it is noted that in an OECD 422 study signs of systemic toxicity were observed meaning that absorption must occur.
Inhalation
The low vapour pressure value (0.11 Pa at 20°C) shows that the substance is not available as a vapour therefore inhalation is not a significant route of exposure.
Dermal
The substance is a liquid, however update via the dermal route is likely to be hindered by the relatively large molecular weight (450) and the presence of the methacrylate group. Further, since the substance is practically insoluble in water dermal uptake is likely to be low.
The substance is not considered to be an irritant or to be corrosive to the skin and no systemic toxicity was observed in those studies. On the basis of read-across to an analogous substance skin sensitisation is not expected.
DISTRIBUTION
Since the molecular weight is reasonable high and the substance is insoluble it is unlikely that the substance is widely distributed throughout the body. However, clear effects on the liver in repeated dose studies suggests that the substance in some form will reach the liver via systemic distribution.
METABOLISM
The results of the genotoxicity assays have shown that genotoxicity is neither enhanced or diminished in the presence of the S9 metabolising system.
EXCRETION
There is no evidence to indicate the route of excretion but insoluble substances are not favourable for urinary excretion in addition excretion via bile is also unlikely. Any test item that is not absorbed will be excreted in the faeces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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