Registration Dossier
Registration Dossier
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EC number: 215-671-7 | CAS number: 1340-06-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because an acute toxicity study by the dermal route does not indicate skin irritation up to the relevant limit dose level (2 000 mg/kg body weight)
- Justification for type of information:
- The acute dermal toxicity of the test substance was determined with doses of 17,800 and 21,500 mg/kg b.w. The skin reaction was checked independently by two investigators with regard to development of erythema as well as edema. No intolerance reactions (no erythema and no edema) were observed up to the highest testing dose.
- no local skin reactions and no specific clinical symptoms were evident in the dose groups applied
- no specific pathological findings were evident on macroscopical examination at the end of the post-observation period (number and kind of organs not specified)
- no changes in body weight development and food intake was observable
- LD50 was estimated to be > 21500 mg/kg b.w. (males and females)
The study design followed provisions of OECD guideline 402.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
