Registration Dossier
Registration Dossier
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EC number: 205-109-9 | CAS number: 133-53-9
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July - August 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- EU Method A.8
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 4-chloro-3,5-xylenol
- EC Number:
- 201-793-8
- EC Name:
- 4-chloro-3,5-xylenol
- Cas Number:
- 88-04-0
- Molecular formula:
- C8H9ClO
- IUPAC Name:
- Phenol, 4-chloro-3,5-dimethyl-
- Test material form:
- solid: crystalline
- Details on test material:
- PCMX
off-white, crystalline solid
Constituent 1
- Specific details on test material used for the study:
- PCMX
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.8
- Temp.:
- 20 °C
- pH:
- 6.1
- Details on results:
- The partition coefficient of PCMX has been determined to be 656, Log10 Pow "" 2.8.
Any other information on results incl. tables
The retention times, capacity factors and Log10 Pow values determined for the
sample are shown
Injection Retention time (mins) Capacity factor (k) Log10 k Log10 Pow
1 7.894 1.91 0.281 2.82
2 7.887 1.91 0.281 2.82
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient of PCMX has been determined to be 656, Log10 Pow "" 2.8.
- Executive summary:
Substances having a Log10 Pow greater than 3 are regarded as having the potential to
bioaccumulate in the environment.
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