Registration Dossier
Registration Dossier
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EC number: 231-453-4 | CAS number: 7560-83-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Die Untersuchungen des Verhaltens von Cyclohexylamin (CHA) und Dicyclohexylamin (DCHA) im Koerper.
- Author:
- Filov VA
- Year:
- 1 968
- Bibliographic source:
- Gig. Tr. Prof. Zabol. 7, 29-33
Materials and methods
- Objective of study:
- absorption
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- 2 rats were exposed to vapor (concentration not mentioned); then amine concentration in blood was determined.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dicyclohexylamine
- EC Number:
- 202-980-7
- EC Name:
- Dicyclohexylamine
- Cas Number:
- 101-83-7
- Molecular formula:
- C12H23N
- IUPAC Name:
- N-cyclohexylcyclohexanamine
- Test material form:
- not specified
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 2 animals were exposed for 80 minutes via inhalation, with no data on doses
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- other: air
- Duration and frequency of treatment / exposure:
- 80min.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
No data
- No. of animals per sex per dose / concentration:
- 2
- Control animals:
- not specified
- Details on study design:
- no details
- Details on dosing and sampling:
- no details
- Statistics:
- no details
Results and discussion
Main ADME results
- Type:
- absorption
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- 0.014 and 0.026 mg DCHA/ml blood were determined indicating that dicyclohexylamine penetrate the alveolar membrane and enter the blood.
- Details on distribution in tissues:
- 0.014 and 0.026 mg DCHA/ml blood were determined indicating that dicyclohexylamine penetrate the alveolar membrane and enter the blood.
- Details on excretion:
- no data
Metabolite characterisation studies
- Metabolites identified:
- not specified
- Details on metabolites:
- no data
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- no data
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: penetrated the alveolar membrane and entered blood stream
- Executive summary:
Following inhalation exposure to DCHA, it was determined in blood indicating that dicyclohexylamine penetrates the alveolar membrane and enters the blood.
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