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Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes
Type of method:
other: capillary/metal block method
Key result
Melting / freezing pt.:
ca. 128.5 °C
Atm. press.:
750.8 mm Hg
Remarks on result:
other: Upon melting, test substance appeared clear.

Determination of Melting Point/Melting Range for the Test Substance

Instrument Gradient (°C/min)

Barometric Pressure (mm Hg)

Start of

Melting Range

°C (K)1

End of Melting Range °C (K)1

Melting Point °C (K)1

112C-304-1

1.0

750.8

128.4 (401.6)

131.3

(404.5) 

128.4 (401.6)

112C-304-2

1.0

750.8

128.6 (401.8)

131.4

(404.6) 

128.6 (401.8)

112C-304-3

1.0

750.8

128.5 (401.7)

131.3

(404.5)

128.5 (401.7)

Overall Means:

750.8

128.5 (401.7)

131.3 (404.5)

128.5 (401.7)

Standard Deviations:

0.0

0.1 (0.1)

0.1 (0.1)

0.1 (0.1)

CV (%):

0.00

0.08 (0.02)

0.04 (0.01)

0.08 (0.02)

1K (Kelvin) = °C + 273.15

Note:All calculations were performed using EXCEL 2010 in full precision mode.

Conclusions:
The melting point for the test substance was 128.5°C (range of 128.5 to 131.3°C) at 750.8 mm Hg.
This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
Executive summary:

A study was performed to determine the melting temperature of the test item according OECD Method 102 and U.S. EPA. Test Guidelines, OPPTS 830.7200. The melting temperature was determined using the caplillary/metal block method . Subsamples of the test substance were heated in melting point capillary tubes in a temperature-controlled heating block. Measurement of melting points was limited to ≤ 400°C (approximately 673K), the maximum specified for the instrumentation used. The temperature at which fine droplets adhered uniformly to the wall of the melting point tube was accepted as the melting point. The definitive melting point testing provided a mean melting point of 128.5 ± 0.1°C (401.7K) and a mean melting range from 128.5 ± 0.1°C (401.7K) to 131.3 ± 0.1°C (404.4K) - for the three tests. Upon melting, the test substance appeared clear.

Description of key information

OECD Guideline 102

Key value for chemical safety assessment

Additional information

Value used for CSA:

128.5°C at 100.1 kPa

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