D-mannose

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Qualifier:

no guideline available

Principles of method if other than guideline:

Neutral Organic Baseline Toxicity for Green Algae 72-h EC50 (For compounds related to monosaccharides)
QPRF and QMRF reports are attached in IUCLID

Specific details on test material used for the study:

Smiles: O=C[C@H]([C@H]([C@@H]([C@H](O)CO)O)O)O

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

> 36 600 mg/L

Basis for effect:

growth rate

Validity criteria fulfilled:

yes

Conclusions:

72-hour EC50 (green algae) > 36600 mg/L

Executive summary:

The Neutral Organic Baseline Toxicity for Green Algae 72-h EC50 (For compounds related to monosaccharides) was used. The model predicts a 72-hour LC50 value of > 36600 mg/L in green algae. Additional supporting documentation is provided in the prediction report attached in IUCLID.

Key value for chemical safety assessment

EC50 for freshwater algae:

36 600 mg/L