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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
TIMES v.2.27.17.6 in QSAR Toolbox
Toolbox prediction report is attached in IUCLID
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
D-mannose
EC Number:
222-392-4
EC Name:
D-mannose
Cas Number:
3458-28-4
Molecular formula:
C6H12O6
IUPAC Name:
D-mannose
Details on test material:
Purity: not reported
Specific details on test material used for the study:
Smiles: OCC{P-}(O)C{P-}(O)C{P+}(O)C{P+}(O)C=O

Results and discussion

In vivo

Results
Irritation parameter:
other: QSAR Eye irritation model
Remarks on result:
no indication of irritation
Remarks:
Model indicates that the test substance is unlikely to be irritating to the eye

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Model indicates that the test substance is unlikely to be irritating to the eye.
Executive summary:

The TIMES model for in vivo eye irritation was used within the QSAR Toolbox. Model indicates that the test substance is unlikely to be irritating to the eye. Additional supporting documentation is provided in the prediction report attached in IUCLID.

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