Registration Dossier

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

Currently viewing:

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
TIMES v.2.27.17.6 in QSAR Toolbox
Toolbox prediction report is attached in IUCLID
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
D-mannose
EC Number:
222-392-4
EC Name:
D-mannose
Cas Number:
3458-28-4
Molecular formula:
C6H12O6
IUPAC Name:
D-mannose
Details on test material:
Purity: not reported
Specific details on test material used for the study:
Smiles: OCC{P-}(O)C{P-}(O)C{P+}(O)C{P+}(O)C=O

Results and discussion

Test results
Key result
Species / strain:
S. typhimurium, other:
Metabolic activation:
with
Genotoxicity:
negative
Remarks on result:
no mutagenic potential (based on QSAR/QSPR prediction)

Applicant's summary and conclusion

Conclusions:
Negative with metabolic activation
Executive summary:

The TIMES model for in vitro bacterial cell mutagenicity was used with the QSAR Toolbox. The prediction was negative with activiation. Additional supporting documentation is provided in the prediction report attached in IUCLID.