Registration Dossier
Registration Dossier
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EC number: 946-353-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
LD50, oral, m/f > 2000 mg/kg bw
LD50, dermal, m/f > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The analogue substance was tested for acute oral toxicity in-vivo studies following OECD 401 (NONS dossier, 1988).
For the acute oral toxicity five males and five females of Wistar were dosed and the LD50, m/f > 2000 mg/kg bw.
Based on the read across considerations same results apply to Reactive Orange 12:1.
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008), table 3.1.1, Acute toxicity hazard categories and acute toxicity estimates (ATE) defining the respective categories:
For Acute toxicity oral route:
Category 1: ATE <= 5 mg/kg bw
Category 2: 5 < ATE <= 50 mg/kg bw
Category 3: 50 < ATE <= 300 mg/kg bw
Category 4: 300 < ATE <= 2000 mg/kg bw
The LD50 of the test substance was determined to be > 5000 mg/kg bw in the chosen reference test, which does not classified the substance.
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