Tetraethyllead

Toxicity to reproduction

Administrative data

Endpoint:

toxicity to reproduction

Remarks:

other: Mating Index of mice

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

3 (not reliable)

Data source

Reference

Reference Type:

publication

Title:

Absence of mutagenic effects after treatment of mice with lead compounds

Author:

Kennedy, G.L., Arnold, D.

Year:

1971

Bibliographic source:

Newsletter Environ. Mut. Soc. Vol 5, pp 37

Materials and methods

Principles of method if other than guideline:

10 males per group were treated with a single dose po (6.48 and 32 mg TEL / kg) or ip (0.65 and 3.2 mg TEL / kg) and then paired with four females per week over six weeks.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Tetraethyllead

EC Number:

201-075-4

EC Name:

Tetraethyllead

Cas Number:

78-00-2

Molecular formula:

C8H20Pb

IUPAC Name:

tetraethylplumbane

Test animals

Species:

mouse

Strain:

not specified

Sex:

male

Administration / exposure

Route of administration:

oral: feed

Details on mating procedure:

Treated males were paired with four females per week over six weeks

Duration of treatment / exposure:

Exposure period: single dose
Premating exposure period (males): Single dose
Premating exposure period (females): no t applicable
Duration of test: 6 weeks

Frequency of treatment:

Single dose

Doses / concentrations

Doses / concentrations 1

Remarks:

Doses / Concentrations:
0.65 & 3.2 mg TEL / kg
Basis:

Doses / concentrations 2

Remarks:

Doses / Concentrations:
6.48 & 32 mg TEL /kg
Basis:

No. of animals per sex per dose:

10

Control animals:

not specified

Results and discussion

Results: P0 (first parental generation)

Reproductive function / performance (P0)

Reproductive performance:

effects observed, treatment-related

Description (incidence and severity):

Reduced the mating index during the first two weeks

Effect levels (P0)

Dose descriptor:

LOAEL

Effect level:

3.2 mg/kg bw/day (actual dose received)

Based on:

test mat.

Sex:

male

Remarks on result:

other: Generation not specified (migrated information)

Overall reproductive toxicity

Reproductive effects observed:

not specified

Any other information on results incl. tables

In a dominant lethal test on mice, 10 males per group were treated with a single dose of TEL p.o. (6.48 and 32 mg/kg bw) or i.p. (0.65 and 3.2 mg/kg bw) and then mated with 4 females per week for 6 weeks.

The preimplantation losses rose after an i.p dose of 3.2 mg/kg bw between weeks 3 and 6 of mating. A significant increase in early resorptions was not observed. Oral administration of 32 mg/kg bw reduced the mating index during the first two weeks.

Applicant's summary and conclusion

Conclusions:

An LOAEL of <3.2 mg/kg bw is reported

The preimplantation losses rose after an i.p dose of 3.2 mg/kg bw between weeks 3 and 6 of mating. A significant increase in early resorptions was not observed. Oral administration of 32 mg/kg bw reduced the mating index during the first two weeks.

Executive summary:

An LOAEL of <3.2 mg/kg bw is reported

In a dominant lethal test on mice, 10 males per group were treated with a single dose of TEL p.o. (6.48 and 32 mg/kg bw) or i.p. (0.65 and 3.2 mg/kg bw) and then mated with 4 females per week for 6 weeks.

The preimplantation losses rose after an i.p dose of 3.2 mg/kg bw between weeks 3 and 6 of mating. A significant increase in early resorptions was not observed. Oral administration of 32 mg/kg bw reduced the mating index during the first two weeks.