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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
6 December 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted according to an internationally recognised method. Test substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2009
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
Inspected on 13 and 14 October 2014 / Signed on 8 April 2015
Type of method:
static method
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
791 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
1 007 Pa

The measured values are presented in the following table:

1. Determination
increasing temperature

2. Determination
decreasing temperature

Temp. in °C

Time

Pressure in hPa

Temp. in °C

Time

Pressure in hPa

20.0

08:30

8.5

48.1

11:03

27.7

28.9

09:00

11.8

39.1

11:35

20.5

38.1

09:30

18.5

30.0

12:20

13.4

47.1

10:00

27.3

21.0

13:40

8.9

56.1

10:24

35.0

15.9

14:50

5.4

The parameters for the linear regression of the graph log (p) vs. 1/T are presented in the following table:

Parameter

Value

Slope

-1833.939236

Intercept

9.153934839

Correlation coefficient r

-0.991050727

Coefficient of determination r2

0.982181544

Using the equation vapour pressures at ambient temperature were calculated as:

Parameter

Value

Unit

Vapour Pressure (20 °C)

791

Pa

Vapour Pressure (25 °C)

1007

Pa

Conclusions:
Using the static method, vapour pressures of 791 Pa at 20 °C and 1007 Pa at 25 °C were determined.
These values were calculated from the regression of 10 individual measurements, which were performed in a temperature range of 15.9 – 56.1 °C.
The measured values for pressure p and temperature T were used to calculate pairs of log p and 1/T. These values were plotted, from the linear regression, vapour pressures at ambient temperature were determined.
Executive summary:

The study was performed in order to determine the vapour pressure of test item according to OCED 104, resp. EU A.4 guideline, using the static method.

The vapour pressure of test item was determined to be 791 Pa at 20°C and 1007 Pa at 25°C.

Description of key information

The vapour pressure of test item was determined to be 791 Pa at 20°C and 1007 Pa at 25°C.

These values were calculated from the regression of10individual measurements, which were performed in a temperature range of 15.9 – 56.1 °C.

Key value for chemical safety assessment

Vapour pressure:
791 Pa
at the temperature of:
20 °C

Additional information

A fully reliable experimental study, conducted according to OECD 104 /EU A4 guideline, using static method, is available. It is considered as a key study, and the result is retained as key data.

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