Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-594-9 | CAS number: 97-61-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Insufficent documentation
Data source
Referenceopen allclose all
- Title:
- Updating the maximisation test for identifying contact allergens.
- Author:
- Kligman, A.M. and Epstein, W.
- Year:
- 1 975
- Bibliographic source:
- Contact Dermatitis, 1, 231 (cited from Opdyke and Letizia 1982)
- Report date:
- 1975
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- Test in volunteers: "Maximisation" test acc. to Kligman 1966
- GLP compliance:
- no
- Type of study:
- other: maximization test
Test material
- Reference substance name:
- 2-methylvaleric acid
- EC Number:
- 202-594-9
- EC Name:
- 2-methylvaleric acid
- Cas Number:
- 97-61-0
- Molecular formula:
- C6H12O2
- IUPAC Name:
- 2-methylpentanoic acid
Constituent 1
In vivo test system
Test animals
- Species:
- human
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: no data
- Vehicle:
- petrolatum
- Concentration / amount:
- 2% in petrolatum
Challengeopen allclose all
- Route:
- other: no data
- Vehicle:
- petrolatum
- Concentration / amount:
- 2% in petrolatum
- No. of animals per dose:
- 25 volunteers
Results and discussion
Any other information on results incl. tables
A concentration of 2 % in petrolatum produced no sensitisation reaction in 25 volunteers.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
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