3-(Hydroxymethyl)-1-pentene

Endpoint summary

Description of key information

The incubated hen egg test revealed a high irritation index. Therefore, the substance was classified as skin corrosion cat. 1A and serious eye damage cat. 1.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Reference

Endpoint:

skin irritation: in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2006

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Remarks:

Only a brief summary of the study is available

Qualifier:

according to guideline

Guideline:

other: Hen's egg test

GLP compliance:

not specified

Irritation / corrosion parameter:

other: hen egg irritation score

Value:

ca. 19.09

Remarks on result:

other: The substance was evaluated in a hen egg irritation assay.

Before testing the test item in rabbits, an alternative method, i.e. the Hen's egg test (HET), was used for an evaluation of possible skin irritating properties of the test item. The irritation scores in this test are:

0 – 0.9: not irritating

1 – 4.9: slightly irritating

5 – 8.9: moderately irritating

9 – 21: severely irritating.

The test revealed an irritation score of 19.09, i.e. a corrosive or severe irritating potential can be expected. Therefore, no in vivo study with rabbits was performed.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (corrosive)

Eye irritation

Link to relevant study records

Reference

Endpoint:

eye irritation: in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2006

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Remarks:

Only a brief summary of the study is available

Qualifier:

no guideline available

Principles of method if other than guideline:

The hen egg irritation score was determined.

GLP compliance:

not specified

Irritation parameter:

other: Hen egg irritation score

Value:

19.09

Remarks on result:

other: The hen egg irritation score was determined.

Before testing the test item in rabbits, an alternative method, i.e. the Hen's egg test (HET), was used for an evaluation of possible eye irritating properties of the test item. The irritation scores in this test are

0 – 0.9: not irritating

1 – 4.9: slightly irritating

5 – 8.9: moderately irritating

9 – 21: severely irritating.

The test revealed an irritation score of 19.09, i.e. a corrosive or severe irritating potential can be expected. Therefore, no in vivo study with rabbits was performed.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Justification for classification or non-classification

The test material showed high potential for skin corrosion and eye damage in the hen egg pretest. Therefore, the test material should be classified as skin corrosive cat. 1A and eye damaging cat. 1.