3-(Hydroxymethyl)-1-pentene

Eye irritation

Administrative data

Endpoint:

eye irritation: in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2006

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Remarks:

Only a brief summary of the study is available

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2006

Report date:

2006

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

The hen egg irritation score was determined.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylbut-3-en-1-ol

EC Number:

610-949-8

Cas Number:

53045-70-8

Molecular formula:

C6H12O

IUPAC Name:

2-ethylbut-3-en-1-ol

Test material form:

liquid

Results and discussion

In vitro

Results

Irritation parameter:

other: Hen egg irritation score

Value:

19.09

Remarks on result:

other: The hen egg irritation score was determined.

Any other information on results incl. tables

Before testing the test item in rabbits, an alternative method, i.e. the Hen's egg test (HET), was used for an evaluation of possible eye irritating properties of the test item. The irritation scores in this test are

0 – 0.9: not irritating

1 – 4.9: slightly irritating

5 – 8.9: moderately irritating

9 – 21: severely irritating.

The test revealed an irritation score of 19.09, i.e. a corrosive or severe irritating potential can be expected. Therefore, no in vivo study with rabbits was performed.