Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-233-7 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility based on available data (OECD 211).
Key value for chemical safety assessment
Additional information
Since no studies investigating the long-term toxicity to aquatic invertebrates of docosyl docosanoate (CAS 17671-27-1) are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to the structurally related category member (Z)-octadec-9-enyl oleate (CAS 3687-45-4) was conducted. The read-across substance is characterized by a similar fatty acid and fatty alcohol chain length. The smaller alcohol and fatty acid chain length increases the water solubility and therefore the bioavailability in water. Water solubility is negatively correlated with the C-chain length of the fatty alcohol and fatty acid (Lide, 2005). Therefore, it is possible to extrapolate from a category member with higher water solubility since it has an increased bioavailability in the water phase (ECHA, 2012). However, the water solubility of both substances is still below the detection limit (< 0.05 mg/L). This read-across is justified in detail in the overall summary (IUCLID section 6.1) and within the category justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. Nevertheless, as it can be seen in the data matrix of the category justification in section 13 and the overall summary, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results.
The study with the read-across substance (Z)-octadec-9-enyl oleate (CAS 3687-45-4) was performed according to OECD 211 with the water flea Daphnia magna under semi-static conditions. Due to the very low water solubility (< 0.05 mg/L) a limit test with a Water Accommodated Fraction (WAF) of nominal 100 mg/L was performed. No effects on reproduction and mortality were recorded after 21 d resulting in a NOELR (21 d) of ≥ 100 mg/L. 0% mortality was recorded in the control whereas 5% mortality was observed in the treatment. This mortality is regarded as natural and tolerated by the test guideline. The chemical analysis resulted in concentrations below the analytical detection limit of 0.0423 mg/L reflecting the very low water solubility of the test item. Based on the result from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a comparable structure, it can be concluded that docosyl docosanoate will not exhibit long-term effects on aquatic invertebrates up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
