Registration Dossier
Registration Dossier
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EC number: 220-239-6 | CAS number: 2682-20-4
Storage stability and reactivity towards container material
Administrative data
- Endpoint:
- storage stability and reactivity towards container material
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February - July 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to guidelines but was conducted according to GLPs and the report contains sufficient data for interpretation of study results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Two samples of the same lot number of Kordek 573T Industrial Microbiocide were submitted for analysis at zero time, one month and three month time points.
- GLP compliance:
- yes
- Type of method:
- ambient testing
Test material
- Test material form:
- other: solid
- Details on test material:
- All Series 63 characterizations of Kordek 573T Industrial Microbicide were done using the Technical Grade Active Ingredient (TGAI). The test material consisted of >95% 2-methyl-4-isothiazol-3-one. Impurities ranged from 0.1 to 1.0% and total less than 5.0%.
Constituent 1
- Specific details on test material used for the study:
- All samples were prepared in a glove box that was purged with nitrogen (relative humidity was <10%). Each sample was melted, and aliquots were transferred into dry, preweighed vials. The sample weight was determined by difference.
The working standard used is RH-573, Lot AAP12269C, 48.7% in Propylene Glycol. The control sample used was Batch 1935 from Technical Grade Lot # 1022 = 51.8%. The samples were prepared in duplicate and each prep was injected in duplicate. The control sample was prepped in duplicate and the preps were analyzed twice, distributed throughout the sequence.
Results and discussion
- Results:
- The test material was stable over a 3 month time period. There was no change in color and physical state of the test material over the three months. In addition, there was no change in the storage container over the three month period.
- Transformation products:
- no
Any other information on results incl. tables
Table 1 Grand Averages for % 573 Samples (Sample #1029)
| Age | % RH-573 |
| Zero Time | 96.8 |
| One Month | 97.1 |
| Three Month | 98.4 |
Applicant's summary and conclusion
- Conclusions:
- Kordek 573T Industrial Microbiocide was stable for at least 3 months.
- Executive summary:
The stability of Kordek 573T Industrial Microbicide was determined over a three month period. Kordek 573T Industrial Microbiocide was stable for at least 3 months.
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