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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not stated in report
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results.
Qualifier:
no guideline available
Principles of method if other than guideline:
Groups of fish were exposed to 14C RH-886 Technica which consists of CMIT and MIT for up to 56 days and subsequently to fresh water for up to 14 days. Water and fish samples were radioassayed at selected intervals.
GLP compliance:
no
Remarks:
prior to GLP implementation
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
Not applicable
Radiolabelling:
yes
Vehicle:
no
Test organisms (species):
Lepomis macrochirus
Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
56 d
Total depuration duration:
14 d
Nominal and measured concentrations:
The concentrations to which the fish were exposed were nominally 0.02, 0.12, and 0.80 ppm of RH-886 for Formulation 1 and 0.12 ppm of RH-886 for Formulation 2.
Reference substance (positive control):
not specified
Type:
BCF
Value:
5.75 dimensionless
Basis:
other: carcass
Calculation basis:
steady state
Remarks on result:
other: Conc.in environment / dose:0.12 ppm
Type:
BCF
Value:
48.1 dimensionless
Basis:
other: viscera
Remarks on result:
other: Conc.in environment / dose:0.12 ppm
Elimination:
yes
Parameter:
DT50
Depuration time (DT):
5 d
Metabolites:
No data
Results with reference substance (positive control):
Not applicable
Details on results:
The steady-state residue values found in the carcass and viscera of fish were determined as follows:

Formulation 1/0.02 ppm of 14C RH-886: 0.609 ppm in carcass and 4.08 ppm in viscera

Formulation 1/0.12 ppm of 14C RH-886: 3.19 ppm in carcass and 18.8 ppm in viscera

Formulation 1/0.8 ppm of 14C RH-886: 17.8 ppm in carcass and 240 ppm in viscera

Formulation 2/0.12 ppm of 14C RH-886 : 0.575 ppm in carcass and 4.81 ppm in viscera

Following exposure of fish to 14C RH-886 labelled on the RH-573 component, the resulting BCF of 14C residues was 5.75 in carcass and 48.1 in viscera.

Elimination of 50% of 14C residues took place in less than 7 days in all cases.

Validity criteria fulfilled:
yes
Conclusions:
Following exposure of fish to 14C RH-886 labelled on the RH-573 component, the resulting BCF of 14C residues was 5.75 in carcass and 48.1 in viscera.

Elimination of 50% of 14C residues took place in less than 7 days in all cases.
Executive summary:

The bioaccumulation potential of 14C labelled MIT was examined in Lepomis macrochirus (bluegill). Fish were exposed to 0.12 ppm MIT under flow through conditions for up to 56 days. Following exposure to the test material, some fish were exposed to fresh water for up to 14 days. After 56 days exposure, 0.575 ppm labelled material was found in the carcass and 4.81 ppm labelled material was found in viscera. Following exposure of fish to 14C RH-886 labelled on the RH-573 component, the resulting BCF of 14C residues was 5.75 in carcass and 48.1 in viscera. Elimination of 50% of 14C residues took place in less than 7 days in all cases.

Description of key information

The bioaccumulation potential of 14C labelled MIT was examined in Lepomis macrochirus (bluegill). Fish were exposed to 0.12 ppm MIT under flow through conditions for up to 56 days. Following exposure to the test material, some fish were exposed to fresh water for up to 14 days. After 56 days exposure, 0.575 ppm labelled material was found in the carcass and 4.81 ppm labelled material was found in viscera. Following exposure of fish to 14C RH-886 labelled on the RH-573 component, the resulting BCF of 14C residues was 5.75 in carcass and 48.1 in viscera. Elimination of 50% of 14C residues took place in less than 7 days in all cases.

Key value for chemical safety assessment

Additional information