Registration Dossier
Registration Dossier
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EC number: 266-411-4 | CAS number: 66576-71-4
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.037 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.004 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 10 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 1.91 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.191 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.361 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Conclusion on classification
There is limited evidence of acute effects with a 96 hr LC50 for fish > 100 mg/L, 48 hr EC50 for aquatic invertebrates >36.795 mg/L and 72 hr EC50 for algae > 44.317 mg/L. The 72 hr NOEC for algae is < 44.317 mg/L, so although Isopropyl 2-methylbutyrate is not classified, a quantitative exposure assessment was conducted for the water, sediment and soil compartment. A PNEC aqua (freshwater) was calculated based on the study endpoints and PNEC values for the soil and sediment compartment were obtained by equilibrium partitioning. Secondary poisoning and exposure through the air compartment were concluded to be not relevant.
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