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EC number: 701-198-8 | CAS number: -
Chemicals placed on the skin undergo absorption into the stratum corneum and evaporation from the surface of the skin. After absorption, the chemicals may be stored in deeper layers of the stratum corneum or in the viable epidermis, or they may penetrate into the dermis for eventual movement into the systemic circulation. Some absorbed compound may also transfer back to the skin surface and evaporate into the surrounding air.
The results are similar to in vitro studies that use diffusion cells and pig skin. The tape-strip data showed evidence of absorption of naphthalene, 1-methyl naphthalene, 2-methyl naphthalene, decane, undecane, and dodecane, although decane seemed to disappear faster from the surface of the stratum corneum. It is estimated that aromatic components of JP-8 penetrate faster than the aliphatic components. The flux of the aliphatic components is greater than the flux of the aromatic components because the concentration of the aliphatics in JP-8 is more than an order of magnitude greater than the concentration of the aromatics. Our overall estimates of the apparent Kp were smaller than the in vitro estimates.
Consequently, the study shows that permeability coefficients estimated in vitro may overestimate the internal dose of various components of JP-8. The results of the study need to be interpreted with caution because in vitro systems do not account for distribution and clearance mechanisms, i.e., processes such as uptake into peripheral tissues, binding to proteins, metabolism, and exhalation are not incorporated in diffusion-cell experiments.
The permeability coefficients (cm/h) of aromatic and aliphatic hydrocarbons were determined to be: Naphthalene 5.3E−05; 1-Methyl naphthalene 2.9E−05; 2-Methyl naphthalene 3.2E−05; Decane 6.5E−06; Undecane 4.5E−07; Dodecane 1.6E−06.
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