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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
pre-GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Remarks:
Pre-GLP
Test type:
standard acute method
Limit test:
yes

Test material

1
Chemical structure
Reference substance name:
[2-(1-ethoxyethoxy)ethyl]benzene
EC Number:
219-868-9
EC Name:
[2-(1-ethoxyethoxy)ethyl]benzene
Cas Number:
2556-10-7
Molecular formula:
C12H18O2
IUPAC Name:
[2-(1-ethoxyethoxy)ethyl]benzene

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10 animals per dose
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
There were no mortalities.
Clinical signs:
other: Slight redness: 3/10 Moderate redness: 5/10 Slight edema: 5/10 Moderate edema: 5/10
Gross pathology:
not specified
Other findings:
No further symptoms were noted.

Applicant's summary and conclusion

Interpretation of results:
other: Not acute toxic
Remarks:
Based on EU CLP Criteria (EC 1272/2008 and its updates)
Conclusions:
An acute dermal toxicity study was performed with Hyacinth body according to a method similar to OECD TG 402. The dermal LD50 was therefore set at >5000 mg/kg/ bw. Based on the results of this study it is concluded that Hyacinth body is not acute dermally toxic.
Executive summary:

An acute dermal toxicity study was performed with Hyacinth body according to a method similar to OECD TG 402 and was rated Klimisch 2 as it was performed comparable to guideline study with acceptable restrictions and pre-GLP. In this study, 10 rabbits were dermally exposed to Hyacinth body at dose level 5000 mg/kg bw. There were no mortalities in this study. The clinical sign noted was a skin irritation demonstrated in slight to moderate redness (in eight animals in total) and slight to moderate edema (in all animals).