Registration Dossier
Registration Dossier
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EC number: 210-194-0 | CAS number: 609-65-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, no concentration of the testing substance was mentioned
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-chlorobenzoyl chloride
- EC Number:
- 210-194-0
- EC Name:
- 2-chlorobenzoyl chloride
- Cas Number:
- 609-65-4
- Molecular formula:
- C7H4Cl2O
- IUPAC Name:
- 2-chlorobenzoyl chloride
- Test material form:
- other: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Housing: Makrolon cage ( Type 3), Room temperature: 22+/- 1.5°C, Daily light time period: 12 hours, humidity: 60+/-5 %, Fed: Altromin R 1324 (Source Altromin GmbH, Lage) and tap water ad libitum.Animals: Source: Winkelmann, Borchen, Age: 9 weeks,
Administration / exposure
- Route of administration:
- oral: gavage
- Details on oral exposure:
- The substance was once administered via metal tube to 10 female animales/dose.
- Doses:
- 1.5,2,2.5,2.8,3,1 ml/kg bw
- No. of animals per sex per dose:
- 10 animals
- Details on study design:
- At the day of administration the animals were inspected several times. After administration the animals were observed for 14 days.
- Statistics:
- Probit analysis (Fink & Hund)
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2.48 mL/kg bw
- 95% CL:
- 2.25 - 2.67
- Clinical signs:
- other: Loss of body weight, tremor,sedation.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the study the calculated LD50 is 2.48 ml/kg bw (for female rats).
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