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Registration Dossier
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EC number: 616-081-6 | CAS number: 743423-33-8
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- March 04, 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 27, 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- column elution method
Test material
- Reference substance name:
- sodium;2-hexadecylsulfanyl-1H-benzimidazole-5-sulfonate
- EC Number:
- 616-081-6
- Cas Number:
- 743423-33-8
- Molecular formula:
- C23 H37 N2 Na O3 S2
- IUPAC Name:
- sodium;2-hexadecylsulfanyl-1H-benzimidazole-5-sulfonate
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 0.034 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 50.7 other: mg (loading for column material)
- Temp.:
- 19.9 °C
- pH:
- >= 7.6 - <= 7.9
Any other information on results incl. tables
The coefficient of variation (CV) (n = 10) was≤ 30% at both flow rates. It demonstrated that the system was equilibrated at all flow rates.
The maximum difference (MD) on the mean values of the samples at both flow rates was also≤ 30%. Based on this, the water solubility of the test item is given as the mean value of these measurements.
The turbidity of the eluates was > 0.2 NTU. Samples were filtered prior to analysis. This filtration step was checked by the two consecutive filtration steps, using the water fraction previously used for the determination of the flow rates (results archived in the raw data). Since even after two filtration steps the measured concentrations were in the same range as the sample the results were considered acceptable.
No test item was detected in the samples from the blank column.
Applicant's summary and conclusion
- Conclusions:
- The column elution method was applied for the determination of the water solubility of V182675.
The water solubility of the test item at 20°C was 0.0342 µg/L.
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