Resinoid of Ferula galbaniflua (Apiaceae) obtained from the exudate by hydrocarbon alcohol extraction.

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

19-20 February 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method, and under GLP. Test substance is adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

Inspected on 13 and 14 October 2014/ Signed on 8 April 2015

Type of method:

method according to Siwoloboff

Key result

Boiling pt.:

132.8 °C

Atm. press.:

>= 99 740 - <= 99 810 Pa

Decomposition:

yes

Decomp. temp.:

>= 120 °C

Findings:

Pre-test:

The following observations were noted:

Observations	Temperatures
Colourless condensate and fine bubbles visible	Since 120 °C
Lots of fine small bubbles	Since 140 °C
Bubble chain, gas burner switched off	150 °C
Bubble chain broke	147.1 °C

After cooling down the colour of the test item was slightly darker.

Main test:

Observations and measured values are presented in the following table:

Observations	Temperatures
	First Determination atmospheric pressure 99810 Pa	Second Determination atmospheric pressure 99740 Pa
Test start: Fine small bubbles and colourless condensate visible.	120.0 °C	120.0 °C
Lots of fine small bubbles	Since 140 °C	Since 140 °C
Boiling chain, gas burner switched off	147.1 °C	149.4 °C
Boiling chain broke	133.1 °C	132.4 °C

After cooling down the colour of the test item was slightly darker.

No calculation following Sydney-Young was carried out as signs of decomposition (change of colour) were considered.

Results:

	Boiling point under decomposition	Pressure in Pa
First determination	133.1 °C (406.3 K)	99810 Pa
Second determination	132.4 °C (405.6 K)	99740 Pa
Mean	132.8°C (405.9 K)

Mean ± standard deviation (without correction following Sydney Young) = 132.8 ± 0.5 °C (405.9 ± 0.5 K).

Conclusions:

The determination of the boiling point of test item was performed following the Siwoloboff Method.
First sign of possibly decomposition indicated by a colourless condensate was observed since 120°C.
Therefore the boiling point of test item should be stated as: 132.8 ± 0.5 °C (405.9 ± 0.5 K) under decomposition of the test item.
This value is the mean of two independent determinations without Sydney-Young correction.

Executive summary:

The study was performed in order to determine the boiling point of test item according to OECD 103, resp. EU A.2, guideline, using the Siwoloboff method.

The boiling point of test item should be stated as: 132.8 ± 0.5 °C (405.9 ± 0.5 K) under decomposition of the test item.

Description of key information

The boiling point of test tiem should be stated as: 132.8 ± 0.5 °C (405.9 ± 0.5 K) under decomposition of the test item.

This value is the mean of two independent determinations without Sydney-Young correction.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:

132.8 °C

Additional information

A fully reliable experimental study, conducted according to OECD 103/ EU A2 guideline is available.

It is considered as a key study, and the result is retained as key data.