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EC number: 216-577-9 | CAS number: 1618-26-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute aquatic toxicity
Daphnia was the most sensitive species in acute toxicity tests with
the test substance, according to OECD guideline, resulting in a 48 -hour
EC50 37.2 mg/L. Based on acute aquatic toxicity results obtained, the
substance has not to be classified according to Regulation (EC) No
1272/2008 (CLP).
Chronic toxicity
The test substance was tested in an aquatic toxicity test with
algae, according to OECD guideline 201. The 72 -hour EC50 and EC10 for
growth rate was > 100 and 32.8 mg/L, and 72 -hour NOEC 7.23 mg/L. Thus,
the substance has not to be classified according to Regulation (EC) No
1272/2008 (CLP).
Based on acute aquatic toxicity results obtained, the substance has not to be classified as environmental acute toxic according to Regulation (EC) No 1272/2008 (CLP). However, as only one chronic endpoint (algae) is available and the substance is not readily biodegradable the acute endpoint from Daphnia is used for chronic classification. The substance has to be classified as environmental chronic toxic cat. 3 (H412) according to Regulation (EC) No 1272/2008 (CLP).
Additional information
Short-term toxicity to invertebrates
In the acute immobilisation test (reference 6.1.3-1) with Daphnia magna (STRAUS), the effects of the test item were determined according to OECD Guideline for testing of chemicals, Guideline No. 202, adopted 13th April 2004. The study was conducted in a static system over a period of 48 hours with nominal concentrations of 6.25, 12.5, 25, 50 and 100 mg/L (corresponding to geometric measured concentrations of 4.2, 7.9, 16.4, 34.0 and 67.8 mg/L). The validity criteria of the test guideline were fulfilled. The EC50 value (48 hours) was determined to be 37.2 mg/L (mean measured).
Toxicity to aquatic algae
The effect of the test item on the growth of a unicellular green algal species Raphidocelis subcapitata was determined according to OECD 201, Regulation (EC) No. 226/2016 Method C.3 and EPA OPPTS 850.5400 and under GLP (reference 6.1.5-1). The study was conducted under static conditions with an initial cell density of 1x10^4 cells/mL for a period of 72 hours. A stock solution of 100 mg/L was freshly prepared with OECD Medium and shaken overnight and the non-dissolved test material was separated by filtration. Five concentrations were tested in a geometrical series with a dilution factor of 3.2: 0.95, 3.05, 9.77, 31.3 and 100 mg/L ((corresponding to 0.63, 2.01, 7.23, 23.5 and 72.3 mg/L (calculated geometric mean concentrations)).The EC50 values for inhibition of growth rate (ErC50) was > 100 mg/L and for inhibition of yield (EyC50) 91.6 mg/L. The EC10 value was determined to be 32.8 mg/L based on growth rate (ErC10) and 2.34 mg/L based on yield (EyC10).
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