Registration Dossier

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Study period:
3 hours
Reliability:
1 (reliable without restriction)
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
Hop extract - CO2 extract of Humulus lupulus variety 'Cascade'. Batch number 160025. Principal components: alpha acids: 35.06% w/w; beta acids: 38.47% w/w; essential oils: 8.92% v/w
Test organisms (species):
activated sludge
Key result
Duration:
3 h
Dose descriptor:
NOEC
Effect conc.:
ca. 100 mg/L
Conc. based on:
act. ingr.
Validity criteria fulfilled:
yes
Conclusions:
Study Conclusion: "The study was conducted according to the test guideline. HOP EXTRACT exhibited some respiration inhibition at 1000mg/l. The definitive test was not required by the sponsor and was, therefore, not performed. HOP EXTRACT also demonstrated no abiotic response.

The 3-hour EC50 of HOP EXTRACT to activated sludge respiration inhibition was determined to be >1000mg/l (using linear interpolation) during the preliminary study.

The NOEC for HOP EXTRACT was determined to be 100mg/l using direct observation."

Description of key information

Key value for chemical safety assessment

EC50 for microorganisms:
1 000 mg/L
EC10 or NOEC for microorganisms:
100 mg/L

Additional information

The EC50 of 1000 mg/l is used for CSR

Study Conclusion: "The study was conducted according to the test guideline. HOP EXTRACT exhibited some respiration inhibition at 1000mg/l. The definitive test was not required by the sponsor and was, therefore, not performed. HOP EXTRACT also demonstrated no abiotic response.

The 3-hour EC50 of HOP EXTRACT to activated sludge respiration inhibition was determined to be >1000mg/l (using linear interpolation) during the preliminary study.

The NOEC for HOP EXTRACT was determined to be 100mg/l using direct observation."

Categories Display