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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2018-05-23 to 2019-02-05
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance
Key result
Temp.:
20 °C
Vapour pressure:
0 Pa
Temp.:
25 °C
Vapour pressure:
0 Pa
Temp.:
50 °C
Vapour pressure:
0 Pa

The vapour pressure was measured in the temperature range of 112 to 153 °C. Due to the fact that the molecular mass of the test item is between 471 and 521 g/mol, the vapour pressure was calculated for a mean molecular mass of 500 g/mol.

Table 1. Results of the effusion method

 No. Temperature / °C  Vapour pressure for M = 500 g/mol /Pa 
 1 112  2.72E-3 
 2 122 3.86E-3 
 3 133 7.59E-3 
 4  143 1.15E-2 
 5  153 1.59E-2 

From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation were derived by regression of the data points to M = 500 g/mol:

A = 5.76

B = -3212.31

C = 273.15

The vapour pressure of the test item calculated by extrapolation for the temperatures 20, 25 and 50 °C is the following:

Table 2. Calculated vapour pressure values for 20, 25, 50 °C

Temperature / °C  Vapour pressure for M = 500 g/mol /Pa 
20 6.34E-6
25 9.68E-6
50 6.60E-5
Conclusions:
The vapour pressure was calculated to be 6.34E-6 Pa at 20 °C, 9.68E-6 Pa at 25 °C and 6.60E-5 Pa at 50 °C, respectively.
Executive summary:

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The vapour pressure of the test item was determined at temperatures between 112 and 153 °C. The vapour pressure was calculated for a mean molecular weight of 500 g/mol. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure was calculated to be 6.34E-6 Pa at 20 °C, 9.68E-6 Pa at 25 °C and 6.60E-5 Pa at 50 °C, respectively.

 

Description of key information

The vapour pressure was calculated to be 6.34E-6 Pa at 20 °C, 9.68E-6 Pa at 25 °C and 6.60E-5 Pa at 50 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The vapour pressure of the test item was determined at temperatures between 112 and 153 °C. The vapour pressure was calculated for a mean molecular weight of 500 g/mol. Using the Antoine equation, the constants A and B were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure was calculated to be 6.34E-6 Pa at 20 °C, 9.68E-6 Pa at 25 °C and 6.60E-5 Pa at 50 °C, respectively.