Registration Dossier
Registration Dossier
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EC number: 220-618-6 | CAS number: 2835-95-2
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
The Adsorption Coefficient, log KOC, of 5-amino-o-cresol for soil was < 1.25 (KOC < 17.78 L/kg) measured by HPLC method (OECD 121). The test item was hence classified as very high mobile in soil (KOC: 0-50), based on McCall classification scheme of soil mobility potential.
Key value for chemical safety assessment
- Koc at 20 °C:
- 17.78
Additional information
The Adsorption Coefficient of 5 -amino-o-cresol was determined following OECD 121 (High Performance Liquid Chromatography (HPLC)) and under GLP.
The determination of the Koc on soil was conducted with a mobile phase consisting of 55% methanol and 45% of double distilled water (pH not reported). Samples of the test material were analyzed in duplicate via HPLC on a cyanopropyl (CN-) column with UV detection. The column temperature was 25°C.
Calibration was performed using seven reference materials with known values of log Koc on soil. Dead time of the HPLC-system was determined with formamide.
The retention time of 5 -amino-o-cresol was 4.070 and 4.062 min. for the main peak during run 1 and run 2 respectively. The retention time of test item was found to be shorter than the retention time of acetanilide (reference material with the lowest Koc value in the standard set). The Adsorption Coefficient, log Koc of 5 -amino-o-cresol (extrapolated) was 0.83 (Koc: 6.76) for soil.
The Adsorption Coefficient, log KOC, of 5-amino-o-cresol for soil , is considered to be < 1.25 (Koc < 17.78 L/kg) which is the lowest value of the tested standards.
The test item was hence classified as very high mobile in soil (KOC: 0-50), based on McCall classification scheme of soil mobility potential.
This study is considered as indicative rather than absolute since the log Koc was not obtained by interpolation and the pH was not indicated.
[LogKoc: 1.25]
[LogKoc: 1.25]
[LogKoc: 1.25]
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