5-amino-o-cresol

Guidance on Safe Use

First-aid measures

DESCRIPTION OF FIRST AID MEASURES

General Information

In case of accident or if you feel unwell, seek medical advice immediately.

Remove contaminated soaked clothing immediately.

After Inhalation

Move to fresh air.

In the event of symptoms seek medical advice.

After Contact With Skin

Wash off immediately with soap and plenty of water. Take off contaminated clothing immediately.

In case of irritation consult a physician.

After Contact With Eyes

Rinse immediately with plenty of water,also under the eyelids,for at least 15 minutes.

If eye irritation persists consult a specialist.

After Ingestion

Rinse out mouth and give plenty of water to drink. Do NOT induce vomiting.

Never give anything by mouth to an unconscious person.

Get medical advice if you fell unwell.

MOST IMPORTANT SYMPTOMS AND EFFECTS, BOTH ACUTE AND DELAYED

May cause sensitisation by skin contact.

INDICATION OF ANY IMMEDIATE MEDICAL ATTENTION AND SPECIAL TREATMENT NEEDED

Treat symptomatically.

Fire-fighting measures

Suitable Extinguishing Media

Water-spray,dry chemical,carbon dioxide,foam.

Extinguishing media which must not be used for safety reasons.

Full water jet.

SPECIAL HAZARDS ARISING FROM THE SUBSTANCE OR MIXTURE

Do not inhale explosion or combustion vapors. Fire will produce acidic smoke.

Fire may produce:

Carbon monoxide

Carbon dioxide

Nitrogen oxides (NOx)

Dust may form explosive mixture in air.

ADVICE FOR FIREFIGHTERS

Wear self-contained breathing apparatus and protective suit.

ADDITIONAL INFORMATION

Water used to extinguish a fire should not be allowed to enter drains,soil or surface waters.

Provide for measures for the retention of product and extinguishing water.

Contaminated extinguishing water and soil must be disposed of in accordance with official regulations.

Cool containers at risk with water spray jet.

Accidental release measures

PERSONAL PRECAUTIONS, PROTECTVE EQUIPMENT AND EMERGENCY PROCEDURES

Avoid dust formation.

Do not breathe dust.

Ensure adequate ventilation.

Respirator must be worn if exposed to dust.

Avoid contact with skin, eyes and clothing.

Use personal protective clothing.

Dust may form explosive mixture in air.

Remove all sources of ignition.

ENVIRONMENTAL PRECAUTIONS

Do not discharge into the drains/surface waters/ground water.

Water used to extinguish a fire should not be allowed to enter drains, soil or surface waters.

Provide for measures for the retention of product and extinguishing water.

Contaminated extinguishing water and soil must be disposed of in accordance with official regulations.

METHODS AND MATERIAL FOR CONTAINMENT AND CLEANING UP

Moisten and pick up mechanically, avoiding dust and provide disposal in suitable recipients.

Handling and storage

PRECAUTIONS FOR SAFE HANDLING

Advice on safe handling

Keep container tightly closed.

Provide appropriate exhaust ventilation at machinery and at places where dust can be generated.

Do not breathe dust.

Avoid contact with skin, eyes and clothing.

Use personal protective equipment.

Advice on protection against fire and explosion

Keep away from sources of ignition.

Dust may form explosive mixture in air.

Avoid formation of dust.

Take measures against electrostatically charging.

CONDITIONS FOR SAFE STORAGE, INCLUDING ANY INCOMPATIBILITIES

Requirements for storage rooms and vessels

Keep containers tightly closed in a dry,well-ventilated place.

Further information on storage conditions

Incompatible with strong oxidizing agents.

Protect from humid air and water.

Protect against light.

Keep away from food, drink and animal feeding stuffs.

SPECIFIC END USE(S)

Oxidative hair dyes and products for colouring eyelashes.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

3077

Shipping information

Proper shipping name and description:

Environmentally Hazardous Substance, Solid, N.O.S.(5-amino-2-methylphenol)

Chemical name:

5-amino-2-methylphenol

Language:

English

Labels:

9,N (fish+tree)

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

3077

Shipping information

Proper shipping name and description:

Environmentally Hazardous Substance, Solid, N.O.S.(5-amino-2-methylphenol)

Chemical name:

5-amino-2-methylphenol

Language:

English

Labels:

9,N (fish+tree)

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

3077

Shipping information

Proper shipping name and description:

Environmentally Hazardous Substance, Solid, N.O.S.(5-amino-2-methylphenol)

Chemical name:

5-amino-2-methylphenol

Labels:

9,N (fish+tree)

Marine pollutant

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

3077

Shipping information

Proper shipping name and description:

Environmentally Hazardous Substance, Solid, N.O.S.(5-amino-2-methylphenol)

Chemical name:

5-amino-2-methylphenol

Labels:

9,N (fish+tree)

Remarks

SpecialProvisions

Exposure controls / personal protection

CONTROL PARAMETERS

Additional Advice On Limit Values

Obey national occupational exposure limits for dust exposure.

Hazard conclusions for workers

Route       Type of effect              Hazard conclusion                            Most sensitive endpoint

Inhalation       Systemic effects - Long-term       DNEL (Derived No Effect Level) 6.601 mg/m³              repeated dose toxicity (Oral)

Inhalation       Systemic effects - Acute              Low hazard (no threshold derived)       

Inhalation       Local effects - Long-term              Low hazard (no threshold derived)       

Inhalation       Local effects - Acute              Low hazard (no threshold derived)       

Dermal       Systemic effects - Long-term       DNEL (Derived No Effect Level)

                           3.226  mg/kg bw/day                            repeated dose toxicity (Oral)

Dermal       Systemic effects - Acute              Low hazard (no threshold derived)       

Dermal       Local effects - Long-term              DNEL (Derived No Effect Level)

                           2.66 µg/cm²                                   sensitisation (skin)

Dermal       Local effects - Acute              DNEL (Derived No Effect Level)

                           2.66 µg/cm²                                   sensitisation (skin)

Eyes       Local effects              No hazards identified       

Hazard conclusions for the general population

Route       Type of effect              Hazard conclusion                            Most sensitive endpoint

Inhalation       Systemic effects - Long-term       DNEL (Derived No Effect Level)

                           1.6475  mg/m³                            repeated dose toxicity (Oral)

Inhalation       Systemic effects - Acute              Low hazard  (no threshold derived)       

Inhalation       Local effects - Long-term              Low hazard (no threshold derived)       

Inhalation       Local effects - Acute              Low hazard (no threshold derived)       

Dermal       Systemic effects - Long-term       DNEL (Derived No Effect Level)

                           1.6132  mg/kg bw/day                            repeated dose toxicity (Oral)

Dermal       Systemic effects - Acute              Low hazard (no threshold derived)       

Dermal       Local effects - Long-term              DNEL (Derived No Effect Level)

                           1.33  µg/cm²                                   sensitisation (skin)

Dermal       Local effects acute              DNEL (Derived No Effect Level)       

                           1.33  µg/cm²                                   sensitisation (skin)

Oral       Systemic effects - Long-term       DNEL (Derived No Effect Level)

                           0.9 mg/kg bw/day                            repeated dose toxicity (Oral)

Oral       Systemic effects - Acute              Low hazard (no threshold derived)       

Eyes       Local effects              No hazards identified       

                    

EXPOSURE CONTROLS

Occupational Exposure Controls

Ensure adequate ventilation especially in confined areas.

Protective and hygiene measures

Do not breathe dust.

Keep away from food, drink and animal feeding stuffs.

When using, do not eat, drink, smoke or sniff.

Avoid contact with eyes, skin and clothing.

Immediately remove all soiled and contaminated clothing.

Wash hands before breaks and immediately after handling the product.

Remove and wash contaminated clothing before re-use.

Respiratory protection

Respirator must be worn if exposed to dust.

Hand Protection

Protective gloves resistant to chemicals with effectiveness dermal of 80%,e.g. made of nitrile, minimum coat thickness 0.4mm, permeation resistance (wear duration) approx. 480 minutes.

Selection according to requirements and testing criteria of EN 374.Additionally,follow recommendations given by the manufacturer of protective gloves.

Eye Protection

Eye wash bottle with pure water (EN 15154).

Tightly fitting goggles (EN 166)..

Skin Protection

Dust resistant protective clothing, e.g. disposable protective clothing for one-time use.

Specific use conditions

PROC 1 Chemical production or refinery in closed process without likelihood of exposure or processes with equivalent containment conditions

Physical form of the used product: Solid (non or low dusty form)

Duration of activity: <= 8.0 h/day

Occupational Health and Safety Management System: Advanced

General ventilation: Basic general ventilation (1-3 air changes per hour) [Effectiveness Inhalation: 0%]

Local exhaust ventilation: No

Respiratory Protection: No

Dermal protection: Yes (Chemically resistant gloves conforming to EN374) and (other) appropriate dermal protection [Effectiveness Dermal: 80%]

Place of use: Indoor

Operating temperature: <= 40.0 °C

PROC 2 Chemical production or refinery in closed continuous process with occasional controlled exposure or processes with equivalent containment conditions

Physical form of the used product: Solid (non or low dusty form)

Duration of activity: <= 8.0 h/day

Frequency of skin contact with the contaminant: Rare contact

Occupational Health and Safety Management System: Advanced

General ventilation: Basic general ventilation (1-3 air changes per hour) [Effectiveness Inhalation: 0%]

Local exhaust ventilation: No

Level of automation of the task: Manual task

Quality of the ventilation: Normal or good ventilation

Respiratory Protection: No

Dermal protection: Yes (Chemically resistant gloves conforming to EN374) and (other) appropriate dermal protection [Effectiveness Dermal: 80%]

Place of use: Indoor

Operating temperature: <= 40.0 °C

Kind of skin contact with the contaminant: Light contact

PROC 3 Manufacture or formulation in the chemical industry in closed batch processes with occasional controlled exposure or processes with equivalent containment condition

Physical form of the used product: Solid (non or low dusty form)

Duration of activity: <= 8.0 h/day

Frequency of skin contact with the contaminant: Rare contact

Occupational Health and Safety Management System: Advanced

General ventilation: Basic general ventilation (1-3 air changes per hour) [Effectiveness Inhalation: 0%]

Local exhaust ventilation: No

Level of automation of the task: Manual task

Quality of the ventilation: Normal or good ventilation

Respiratory Protection: No

Dermal protection: Yes (Chemically resistant gloves conforming to EN374) and (other) appropriate dermal protection [Effectiveness Dermal: 80%]

Place of use: Indoor

Operating temperature: <= 40.0 °C

Application rate: <= 1.0 L/min

Kind of skin contact with the contaminant: Light contact

Skin surface potentially exposed: Both hands (820 cm²)

Use rate of the product: <= 2.0 L/min  During 10 minutes

PROC 4 Chemical production where opportunity for exposure arises

Physical form of the used product: Solid (non or low dusty form)

Duration of activity: <= 8.0 h/day

Frequency of skin contact with the contaminant: Rare contact

Occupational Health and Safety Management System: Advanced

General ventilation: Basic general ventilation (1-3 air changes per hour) [Effectiveness Inhalation: 0%]

Local exhaust ventilation: No

Level of automation of the task: Manual task

Quality of the ventilation: Normal or good ventilation

Respiratory Protection: No

Dermal protection: Yes (Chemically resistant gloves conforming to EN374) and (other) appropriate dermal protection [Effectiveness Dermal: 80%]

Place of use: Indoor

Operating temperature: <= 40.0 °C

Kind of skin contact with the contaminant: Light contact

Skin surface potentially exposed: Both hands (820 cm²)

Use rate of the product: <= 2.0 L/min  During 10 minutes

PROC 5 Mixing or blending in batch processes

Physical form of the used product: Solid (non or low dusty form)

Duration of activity: <= 8.0 h/day

Frequency of skin contact with the contaminant: Rare contact

Occupational Health and Safety Management System: Advanced

General ventilation: Basic general ventilation (1-3 air changes per hour) [Effectiveness Inhalation: 0%]

Local exhaust ventilation: No

Level of automation of the task: Manual task

Quality of the ventilation: Normal or good ventilation

Respiratory Protection: No

Dermal protection: Yes (Chemically resistant gloves conforming to EN374) and (other) appropriate dermal protection [Effectiveness Dermal: 80%]

Place of use: Indoor

Operating temperature: <= 40.0 °C

Kind of skin contact with the contaminant: Light contact

Skin surface potentially exposed: Both hands (820 cm²)

Use rate of the product: <= 2.0 L/min  During 10 minutes

PROC 8a Transfer of substance or mixture (charging and discharging) at non-dedicated facilities

Physical form of the used product: Solid (non or low dusty form)

Duration of activity: <= 8.0 h/day

Frequency of skin contact with the contaminant: Rare contact

Occupational Health and Safety Management System: Advanced

General ventilation: Basic general ventilation (1-3 air changes per hour) [Effectiveness Inhalation: 0%]

Local exhaust ventilation: No

Level of automation of the task: Manual task

Quality of the ventilation: Normal or good ventilation

Respiratory Protection: No

Dermal protection: Yes (Chemically resistant gloves conforming to EN374) and (other) appropriate dermal protection [Effectiveness Dermal: 80%]

Place of use: Indoor

Operating temperature: <= 40.0 °C

Kind of skin contact with the contaminant: Light contact

Skin surface potentially exposed: Both hands (820 cm²)

Use rate of the product: <= 2.0 L/min  During 10 minutes

PROC 8b Transfer of substance or mixture (charging and discharging) at non-dedicated facilities

Physical form of the used product: Solid (non or low dusty form)

Duration of activity: <= 8.0 h/day

Frequency of skin contact with the contaminant: Rare contact

Occupational Health and Safety Management System: Advanced

General ventilation: Basic general ventilation (1-3 air changes per hour) [Effectiveness Inhalation: 0%]

Local exhaust ventilation: No

Level of automation of the task: Manual task

Quality of the ventilation: Normal or good ventilation

Respiratory Protection: No

Dermal protection: Yes (Chemically resistant gloves conforming to EN374) and (other) appropriate dermal protection [Effectiveness Dermal: 80%]

Place of use: Indoor

Operating temperature: <= 40.0 °C

Kind of skin contact with the contaminant: Light contact

Skin surface potentially exposed: Both hands (820 cm²)

Use rate of the product: <= 2.0 L/min  During 10 minutes

PROC 9 Transfer of substance or mixture into small containers (dedicated filling line, including weighing)

Physical form of the used product: Solid (non or low dusty form)

Duration of activity: <= 8.0 h/day

Frequency of skin contact with the contaminant: Rare contact

Occupational Health and Safety Management System: Advanced

General ventilation: Basic general ventilation (1-3 air changes per hour) [Effectiveness Inhalation: 0%]

Local exhaust ventilation: No

Level of automation of the task: Manual task

Quality of the ventilation: Normal or good ventilation

Respiratory Protection: No

Dermal protection: Yes (Chemically resistant gloves conforming to EN374) and (other) appropriate dermal protection [Effectiveness Dermal: 80%]

Place of use: Indoor

Operating temperature: <= 40.0 °C

Kind of skin contact with the contaminant: Light contact

Skin surface potentially exposed: Both hands (820 cm²)

Use rate of the product: <= 2.0 L/min  During 10 minutes

PROC 15 Use as laboratory reagent

Physical form of the used product: Solid (non or low dusty form)

Duration of activity: <= 0.25 h/day

Occupational Health and Safety Management System: Advanced

General ventilation: Basic general ventilation (1-3 air changes per hour) [Effectiveness Inhalation: 0%]

Local exhaust ventilation: No

Respiratory Protection: No

Dermal protection: Yes (Chemically resistant gloves conforming to EN374) and (other) appropriate dermal protection [Effectiveness Dermal: 80%]

Place of use: Indoor

Operating temperature: <= 40.0 °C

PROC 28 equivalent PROC 8b: Manual maintenance (cleaning and repair) of machinery

Physical form of the used product: Solid (non or low dusty form)

Duration of activity: <= 8.0 h/day

Frequency of skin contact with the contaminant: Rare contact

Occupational Health and Safety Management System: Advanced

General ventilation: Basic general ventilation (1-3 air changes per hour) [Effectiveness Inhalation: 0%]

Local exhaust ventilation: No

Level of automation of the task: Manual task

Quality of the ventilation: Normal or good ventilation

Respiratory Protection: No

Dermal protection: Yes (Chemically resistant gloves conforming to EN374) and (other) appropriate dermal protection [Effectiveness Dermal: 80%]

Place of use: Indoor

Operating temperature: <= 40.0 °C

Kind of skin contact with the contaminant: Light contact

Skin surface potentially exposed: Both hands (820 cm²)

Use rate of the product: <= 2.0 L/min  During 10 minutes

Environmental exposure controls

There is no risk for the environment at the consumer step and when the risk management measures are applied, the risks for the environment are controlled at the formulation step.

Risk Management Measures at the formulation site :

No air emission controls are required.

Soil emission controls are not applicable as there is no direct release to soil.

Risk management measures are proposed to limit the releases to the aquatic environment. RCR based on CHESAR and Msafe level were calculated. A generic risk assessment was done with the assumption that only one formulation site is using 100 t/y (worst case approach), and taking into account the Cosmetic Europe SpERCs (medium scale 2.1.fv2). Risk Management Measures may be to limit the quantity of substance used on the formulation site to 11 T/y or if 100T/y is used in the formulation plant to treat onsite the wastewaters with an effectiveness ≥ 88.75%. Moreover the formulation plant has to be connected to a municipal sewage treatment plant.

External treatment and disposal of waste should comply with applicable local and/or national regulations.

Risk Management Measures for the consumers :

Avoid releases to the environment and dispose of contents/container at a licensed facility.

Hazard assessment conclusion for the environment

Compartment                     Hazard conclusion

Freshwater                     PNEC aqua (freshwater): 24.0 µg/L

Marine water              PNEC aqua (marine water): 2.4 µg/L

Sediments (freshwater)              PNEC sediment (freshwater): 0.129  mg/kg sediment dw

Sediments (marine water)              PNEC sediment (marine water): 0.0129  mg/kg sediment dw

Sewage treatment plant              PNEC STP: 1.5 mg/L

Soil                     PNEC soil: 0.0117 mg/kg soil dw

Air                     no hazard identified

Secondary poisoning              no potential for bioaccumulation       

Stability and reactivity

REACTIVITY

No decomposition if stored and applied as directed.

CHEMICAL STABILITY

Stable under normal conditions.

POSSIBILITY OF HAZARDOUS REACTIONS

Risk of dust explosions.

CONDITIONS TO AVOID

To avoid thermal decomposition, do not overheat.

Avoid development of dust.

Avoid exposure to light, humid air and water.

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

HAZARDOUS DECOMPOSITION PRODUCTS

Carbon monoxide, carbon dioxide and nitrogen oxides.

Disposal considerations

WASTE TREATMENT METHODS

Advice On Disposal

Dispose of product and contaminated package to landfill/suitable incineration plant according to local regulations.

Where possible recycling is preferred to disposal.

Waste disposal number of waste from residues/unused products

070704

WASTES FROM ORGANIC CHEMICAL PROCESSES; wastes from the MFSU of fine chemicals and chemical products not otherwise specified; other organic solvents, washing liquids and mother liquors. Classified as hazardous waste.

Contaminated Packaging

Contaminated packaging should be emptied as far as possible and after appropriate cleansing may be taken for reuse.

Packaging that cannot be cleaned should be disposed of like the product.