Reaction mass of 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium chloride and 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazol-3-ium chloride dihydrate

Explosiveness

Link to relevant study record(s)

Reference

Endpoint:

explosiveness, other

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23 Aug - 29 Aug 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.14 (Explosive properties)

Version / remarks:

adopted in 2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: OECD 113 Screening test for thermal stability and stability in air

Deviations:

no

GLP compliance:

no

Specific details on test material used for the study:

Storage conditions: ambient temperature (10 to 30 °C), dry

Parameter:

other: Thermal stability via DSC measurement.

Remarks on result:

other: The heat of decomposition was < 500 J/g. The main test on explosive properties was not required.

Results
Thermal Stability
Two DSC-measurements showed an endothermal effect in the temperature range of 145 – 180 °C and an exothermal effect in the range of 185 – 250 °C with a maximum energy of 115 J/g. The measurement was terminated at 500 °C.

A third DSC measurement showed an endothermal effect in the temperature range of 115 – 170 °C and an exothermal effect in the range of 175 – 250 °C with a maximum energy of 140 J/g. The measurement was terminated at 500 °C.

Table 1 – Thermal Stability (DSC measurements)

Weight [mg]	Final temperature [°C]	Temperature range [°C]	Type of effect	Energy [J/g]
10.56	500	145 – 175 190 – 250	Endothermal Exothermal	n.r. 57
10.43		140 – 180 185 – 250	Endothermal Exothermal	n.r. 115
10.76		115 – 170 175 – 250	Endothermal Exothermal	n.r. 140

n.r.: not relevant

Explosive Properties
The heat of decomposition was below 500 J/g, therefore the main test on explosive properties was not necessary.

Description of key information

Not explosive (EU Method A.14., Thermal Stability)

Key value for chemical safety assessment

Explosiveness:

non explosive

Additional information

Heat of decomposition determined by Differential Scanning Calorimetry was below 500 J/g. Main test on explosive properties not necessary.

Justification for classification or non-classification

The available data on explosive properties of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008, and are therefore conclusive but not sufficient for classification: The exothermic decomposition energy is less than 500 J/g.