Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 March 2016 to 20 July 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
N-2-hydroxyethylacetamide
EC Number:
205-530-8
EC Name:
N-2-hydroxyethylacetamide
Cas Number:
142-26-7
Molecular formula:
C4H9NO2
IUPAC Name:
N-2-hydroxyethylacetamide
Test material form:
liquid

Results and discussion

Water solubility
Key result
Temp.:
20 °C
pH:
5.6 - 7.3
Remarks on result:
completely miscible

Any other information on results incl. tables

Sample

Concentration (% w/w)

Observations

Solution pH

1

5.07

Single phase, clear, colourless solution.

5.6

2

50.0

Single phase, pale straw-coloured solution.

6.3

3

94.8

Single phase, straw-coloured solution

7.3

Applicant's summary and conclusion

Conclusions:
The test item has been determined to be miscible with water in all proportions at 20.0 ± 0.5 °C.
Executive summary:

The test substance was miscible with water in all proportions at 20.0 ± 0.5 °C, by visual assessment using a flask method at 5, 50 and 95% w/w, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.