Dodecenylsuccinic acid, compound with 2,2',2''-nitrilotriethanol (1:1)

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Justification for type of information:

Although performed using recognised HPLC method (and GLP) and although many details are included, the report is lacking in some detail and was not fully calibrated for materials with very low Log Kow. However, the study was considered adequate to conclude that there is very little risk of accumulation.

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

GLP compliance:

yes

Type of method:

HPLC method

Specific details on test material used for the study:

Commercial material supplied with ca 45% actives in water.
A water/methanol mobile phase was used so the presence of water will not have impactedon the outcome of the study; the test material dissolved in the mobile phase.

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

< 0

Temp.:

20 °C

pH:

ca. 6.2

Details on results:

Note that the temperature and pH are not reported.
However, the work was performed at 'room temperature' and that the substance is pH 6.2 (range 6 - 7) when diluted in water.
There will be some dissociation effects, so pH will have an impact on the solubility parameters, but testing at a neutral pH will reflect environmental conditions.

Conclusions:

The substance is soluble in water with an expected low partition coefficient value.
Commercial material supplied with ca 40% actives in water.
A water/methanol mobile phase was used so the presence of water will not have impactedon the outcome of the study; the test material dissolved in the mobile phase.
The work was performed at 'room temperature' and that the substance is neutral when diluted in water. There will be some dissociation effects, so pH will have an impact on the solubility parameters.
The substance biodegrades well, so these shortcomings on the test work do not impact on the vPvB / PBT assessment.
The substance is also surface active making comparative concentrations difficult to validate.

Description of key information

HPLC method performed, but was not fully calibrated for materials with Log Kow < 0

The substance is miscible in water (supplied as ca 45% solution in water) so is expected to have a low potential for accumulation

The study was performed at 'room temperature' and is considered to be ca 20 C for the purposes of this summary.

The substance is also surface active making comparative concentrations difficult to validate.

Key value for chemical safety assessment

Log Kow (Log Pow):

0

at the temperature of:

20 °C