Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Endpoint summary

Currently viewing:

Administrative data

Description of key information

There are no studies available on skin sensitisation potential of barium di(acetate) available.

However, a GMPT study with barium dichloride was performed in 2010 and based on the results no evidence on skin sensitisation was observed.

Furthermore, a QSAR calculation (Skin Sensitization model (CAESAR) - v. 2.1.6) was performed with acetic acid. Based on the model outcome “acetic acid” may be considered as a non-sensitising substance in the sense of Regulation (EC) No 1907/2006.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

Read-across concept:

Barium di(acetate)completely dissolves upon contact with water to Ba2+and 2*CH3COO-. The water solubility (CRC handbook, 2008) of barium di(acetate) indicates a complete dissolution and a rapid formation of Ba2+and 2*CH3COO-(792 mg/L at 25°C). The pH of a saturated aqueous solution of barium di(acetate) is pH 7.9. Considering that systemic human health effects of barium di(acetate) are due the dissolved concentrations of Ba2+and CH3COO-in physiological solutions, read-across to soluble (i.e., > 10 g/L at room temperature) inorganic barium compounds and acetic acid and its salts (i.e., > 10 g/L at room temperature) is performedand considered to be very conservative.

Justification for classification or non-classification

Based on read-across from barium dichloride and acetic acid to barium di(acetate), the substance does not require classification in accordance with regulation (EC) No 1907/2006 (REACH) Annex VII section 8.3.