Nonafluoro(trifluoromethyl)cyclopentane

Bioaccumulation: aquatic / sediment

Administrative data

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Justification for type of information:

It is well established that saturated perfluorocarbons form a class of chemicals with very similar properties.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Test guideline

Guideline:

OECD Guideline 305 A (Bioaccumulation: Sequential Static Fish Test)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Perfluoroperhydrophenanthrene

EC Number:

400-470-0

EC Name:

Perfluoroperhydrophenanthrene

Cas Number:

306-91-2

Molecular formula:

C14F24

IUPAC Name:

1,1,2,2,3,3,4,4,4a,4b,5,5,6,6,7,7,8,8,8a,9,9,10,10,10a-Tetracosafluorophenanthrene

Test material form:

liquid

Radiolabelling:

no

Test solutions

Vehicle:

yes

Remarks:

HCO-20 (x10) ad F-142D Megafac (x20)

Test organisms

Test organisms (species):

Cyprinus carpio

Details on test organisms:

Sterilised in static solution of chlorotetracycline hydrochloride (10 mg/l) for 24 hours, acclimatised for 14 days.
Average: body weight 22.4g; length 9.7 cm, lipid content 4.2%.

Study design

Route of exposure:

aqueous

Justification for method:

other: Done to support entry into Japanese market at that time

Test type:

flow-through

Water / sediment media type:

natural water

Total exposure / uptake duration:

ca. 8 wk

Test conditions

Test temperature:

23 to 27°C

Dissolved oxygen:

3.0 to 5.4 mg/l

Nominal and measured concentrations:

Level 1: nominal 1.0 mg/l, measured at 0.807, 0.858, 0.846, 0.839
Level 2: nominal 0.1 mg/l; measured at 0.0790, 0.0832, 0.0867, 0.0889

Reference substance (positive control):

not specified

Results and discussion

Bioaccumulation factor

Bioaccumulation factor 1

Key result

Conc. / dose:

> 0.8 - < 0.9 mg/L

Temp.:

>= 23 - <= 27 °C

Type:

BCF

Value:

>= 0.2 - <= 4.7 dimensionless

Basis:

whole body w.w.

Time of plateau:

8 wk

Bioaccumulation factor 2

Conc. / dose:

> 0.08 - < 0.09 mg/L

Temp.:

>= 23 - <= 27 °C

Type:

BCF

Value:

>= 7.3 - <= 30 dimensionless

Basis:

whole body w.w.

Time of plateau:

8 wk

Applicant's summary and conclusion

Conclusions:

The material exhibits minimal bioconcentration.

Executive summary:

The material exhibits minimal bioconcentration.