Registration Dossier
Registration Dossier
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EC number: 217-298-5 | CAS number: 1805-22-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7 days
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Nonafluoro(trifluoromethyl)cyclopentane
- EC Number:
- 217-298-5
- EC Name:
- Nonafluoro(trifluoromethyl)cyclopentane
- Cas Number:
- 1805-22-7
- Molecular formula:
- C6F12
- IUPAC Name:
- 1,1,2,2,3,3,4,4,5-Nonafluoro-5-(trifluoromethyl)cyclopentane
- Test material form:
- other: liquid
- Details on test material:
- Room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Temperature 16-21 degrees C
Humidity 56-66%
12 hours light and 12 hours darkness
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- 0.5ml of material was introduced under a 2.5cm square gauze patch and placed on the back onto shorn skin. This was secured with tape and an
elasticated corset. - Duration of exposure:
- 4 hours
- Doses:
- once
- No. of animals per sex per dose:
- 3
- Control animals:
- not required
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- discriminating dose
- Effect level:
- ca. 0.5 other: ml
- Based on:
- test mat.
- Mortality:
- N/A
- Clinical signs:
- One animal showed very slight erythema one hour after patch removal and at 24, 48 and 72 hour observations.
- Body weight:
- 2.29 - 2.63kg at start of test
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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