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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
7 days
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Nonafluoro(trifluoromethyl)cyclopentane
EC Number:
217-298-5
EC Name:
Nonafluoro(trifluoromethyl)cyclopentane
Cas Number:
1805-22-7
Molecular formula:
C6F12
IUPAC Name:
1,1,2,2,3,3,4,4,5-Nonafluoro-5-(trifluoromethyl)cyclopentane
Test material form:
other: liquid
Details on test material:
Room temperature

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
Temperature 16-21 degrees C
Humidity 56-66%
12 hours light and 12 hours darkness

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
0.5ml of material was introduced under a 2.5cm square gauze patch and placed on the back onto shorn skin. This was secured with tape and an
elasticated corset.
Duration of exposure:
4 hours
Doses:
once
No. of animals per sex per dose:
3
Control animals:
not required

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
discriminating dose
Effect level:
ca. 0.5 other: ml
Based on:
test mat.
Mortality:
N/A
Clinical signs:
One animal showed very slight erythema one hour after patch removal and at 24, 48 and 72 hour observations.
Body weight:
2.29 - 2.63kg at start of test

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met