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EC number: 207-856-6 | CAS number: 498-15-7
Table 7.1.1/1: Data on the renal excretion kinetics of 3-caren-10-carboxylic acid after oral intake of 10 mg (+)-3-carene by four healthy human volunteers
RE,max maximum renal excretion; tmax time to reach maximum renal excretion; t1/2 elimination half-life; AUC0→tf area under the renal excretion vs. time curve (from time 0 to final sampling timetf);Vtotal summarized excreted urine volume
a Values calculated from the log-normal fitted mean renal elimination curve (n=4)
b Values calculated from the individual excretion data
In a metabolism study, four healthy human volunteers were orally exposed to a single dose of 10 mg delta-3 -carene [(+)-delta-3-carene] via spiked gelatin capsules. Each volunteer gave one urine sample before administration and subsequently collected each urine sample within 24 h after administration. The concentration of the proposed CRN metabolites delta-3-caren-10-ol (CRN-10-OH), delta-3 -caren-10-carboxylic acid (chaminic acid, CRN-10-COOH), and delta-3-caren-3,4-diol (CRN-3,4-OH) were determined using a very specific and sensitive GC-MS/MS procedure. Other CRN metabolites were investigated using GC-PCI-MS Q1 scan analyses.
CRN-10-COOH was detected in each urine sample with maximum concentration (113.0-1172.9 µg/L)) 2-3 h after administration, whereas CRN-10-OH and CRN-3,4-OH were not detected in any of the samples. The renal excretion kinetics of CRN-10-COOH showed an elimination half-life of about 3 h. The cumulative excretion of CRN-10-COOH within 24 h after exposure correlated with about 2% of the applied dose. The GC-PCI-MS Q1 scan analysis indicated several additional human CRN metabolites: 3% (CRN-M1), 1% (CRN-M2), 5% (CRNM3), 4% (CRN-M4), 11% (CRN-M5), and 2% (CRNM6), respectively.
The results of the study indicate that CRN-10-COOH is a relevant product of the human in vivo metabolism of delta-3-carene.
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