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EC number: 207-856-6 | CAS number: 498-15-7
delta-3-Carene was tested for acute dermal toxicity in New Zealand White rabbit in a limit dose assay. 10 rabbits were administered a single dermal dose of delta-3-carene at 5000 mg/kg bw on clipped skin using an occlusive patch for 24 hours. All animals were observed for mortality, body weights and dermal reactions for 7 days. Animals were killed at the end of the study and subjected to necropsy for macroscopical examination.
No deaths occurred throughout the study. At necropsy, macroscopic examination of main organs showed no abnormalities. Adverse dermal reactions noted were slight to moderate erythema and edema. Normal body weight gain was observed in all animals. The acute dermal LD50 was greater than 5000 mg/kg bw.
The acute dermal LD50 of delta-3-carene is greater than 2000 mg/kg bw in rabbits and therefore it is not classified according to Directive 67/548/EEC and CLP Regulation (EC) N° 1272/2008.
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