Registration Dossier
Registration Dossier
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EC number: 209-968-0 | CAS number: 599-64-4
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Evidence of the lack of persistency for p-Cumylphenol was concluded from the results of assessment of the chemical structure using the BIOWIN model in the EPISuite program. The BIOWIN results for p-Cumylphenol are as follows:
• non-linear model (BIOWIN2) prediction: Biodegrades fast (0.72) or
• MITI non-linear model (BIOWIN6) prediction: Does not Biodegrade fast (0.17) and
• ultimate biodegradation timeframe (BIOWIN3) prediction: Weeks-months (2.6)
Based on these results and information available in the European Commission (2003) Technical Guidance Document on Risk Assessment, p-Cumylphenol would not be considered Persistent or Very Persistent.
A reliable QSAR model was used to calculate the bioaccumulation potential of p-Cumylphenol. BCF values were calculated using the BCFBAF v3.01 module embedded within the EPISuite v4.11) computer model. The calculated BCF (regression-based model) was 149 L/kg wet-wt., while the BAF (Arnot-Gobas upper trophic) was 173 L/kg wet-wt. These values are supported by an experimental bioaccumulation study reported on the J-Check website with BCF values ranging from 69 to 190 L/kg. None of these values would classify p-Cumylphenol as Bioaccumulative or Very Bioaccumulative.
Predicted and measured chronic aquatic toxicity tests indicate the substance does not meets the criteria to be regarded as toxic (T). Furthermore p-Cumylphenol is not classified as carcinogenic, germ cell mutagenic, or toxic for reproduction or STOT.
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