Registration Dossier
Registration Dossier
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EC number: 209-968-0 | CAS number: 599-64-4
Endpoint summary
Administrative data
Description of key information
The acute aquatic toxicity of p-Cumylphenol was investigated on three trophic levels: algae, aquatic invertebrates, and fish.
A reliable algae growth inhibition test to OECD Guideline 201 was performed wth P. subcapitata at concentrations of p-Cumylphenol ranging from 0.3 to 17.5 mg/L for 72 hours under static conditions with continuous illumination. Under the conditions of this study, the 48 and 72 hour EC50 values, with respect to algal growth rate were 1.0 and 1.4 mg/L, respectively. The 48 and 72 hour NOEC were determined to be 0.5 and 0.9 mg/L.
An acute immobilisation test was conducted with Daphnia magna according to OECD Guideline 202. Daphnia were exposed to concentrations of p-Cumylphenol ranging from <0.2 to 9.2 mg/L for 48 hours under static conditions with a 16/8 light/dark cycle. Under the conditions of this study, the EC50 concentrations at 24 and 48 hours were 1.6 and 0.9 mg/L, respectively. The NOECs at 24 and 48 hours were 1.1 and 0.6 mg/L, respectively. The LOECs at 24 and 48 hours were 2.2 and 1.1 mg/L, respectively.
An acute fish toxicity test was conducted with Oncorhynchus mykiss according to OECD Guideline 203. O. mykiss were exposed to concentrations of p-Cumylphenol ranging from <0.2 to 9.2 mg/L for 96 hours under static conditions. Under the conditions of this study, the LC50 for p-Cumylphenol exposure was determined to be 0.9 mg/L at 24, 48, 72 and 96 hours.
Additionally, a reliable QSAR model (Ecological Structure-Activity Relationship (ECOSAR) version 1.11) was used to predict the chronic aquatic toxicity of p-Cumylphenol to fish and daphnids. The fish 30 day ChV’s were 0.208 mg/L and 0.501 mg/L for the phenols class and neutral organic class, respectively. These values can be converted to NOECs of 0.147 mg/L and 0.354 mg/L. The daphnid 21 day ChV’s were 0.201 mg/L and 0.438 mg/L for the phenols class and neutral organic class, respectively. These values can be converted to NOECs of 0.142 mg/L and 0.309 mg/L.
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No. 1272/2008, the substance requires classification with respect to aquatic toxicity as Acute Category 1 (H400: Very toxic to aquatic life) and Chronic Category 2 (H411: Toxic to aquatic life with long lasting effects).
Additional information
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