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Toxicity to microorganisms

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Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
Deviations:
no
GLP compliance:
yes
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: General Electric Company, Sample Reference No. 2000 0863
- Purity: 98-100%
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
other: Bacterial seed (Polyseed)
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
28 d
Nominal and measured concentrations:
Nominal: 18.0 +/- 3 mg/L
Reference substance (positive control):
yes
Remarks:
Sodium Acetate
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
18 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: No effect in Toxicity Control

Table 1:Oxygen Determinations over 28-Day Incubation Period         

Bottle Contents

Dissolved Oxygen (mg/L)

Day 0

Day 7

Day 14

Day 21

Day 28

Test Control

7.7

7.3

7.3

7.0

6.9

7.7

7.4

6.9

7.1

6.9

Bottle Contents

Dissolved Oxygen (mg/L)

Day 0

Day 7

Day 14

Day 21

Day 28

Test Substance:

PCP

7.7

7.6

7.1

7.3

7.0

7.7

7.6

7.2

7.1

6.8

Procedure Control:

Sodium Acetate

7.7

3.2

3.2

3.0

2.6

7.7

3.6

3.1

3.0

3.0

Toxicity Control: Sodium Acetate and PCP

7.7

3.5

3.6

3.0

3.7

Table 2: Kinetics for test substance

Day

% Dmean of
PCP

% Dmean of
Reference Substance

0

0.0

0.0

7

-0.4

72.0

14

-0.1

72.0

21

-0.2

74.0

28

+0.1

75.0

Validity criteria fulfilled:
yes
Conclusions:
In an OECD Test Guideline 301D study, a nominal concentration of 18 mg/L p-cumylphenol did not adversely affect the biodegradation of the positive control substance (Sodium Acetate) in the toxicity control study.
Executive summary:

A concentration of 18 mg/L p-cumylphenol resulted in no adverse effects to the biodegradation of Sodium Acetate in the toxicity control of a ready biodegradability study.

Description of key information

A concentration of 18 mg/L p-cumylphenol resulted in no adverse effects to the biodegradation of Sodium Acetate in the toxicity control of a ready biodegradability study.

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
18 mg/L

Additional information